姓名：位珂珂
邮箱：kekewei@sdu.edu.cn
个人简介/Personal resume
位珂珂，副研究员，硕士生导师，华中科技大学基础医学博士。从事代谢、免疫与疾病发生发展的分子机制研究，聚焦代谢重编程调控细胞功能和女性生殖障碍相关疾病（疾病微环境稳态）， 以第一/通讯作者在Signal Transduct Target Ther、Nat Commun、Redox Biol、Cancer Immunol Res等领域权威期刊发表SCI论文10余篇，授权国家发明专利2件。承担多项国家及省部级科研项目，包括主持国家自然科学基金项目2项，省自然科学基金项目1项，中国博士后科学基金特别资助项目1项，作为课题骨干参与国家重点研发计划1项。参加ASPIRE、ACRI、中国免疫学会全国免疫学学术大会等国内外际学术会议并作大会报告，兼任山东省医学会医学教育分会青年学组委员、《Phenomics》《Medicine Bulletin》青年编委等
研究领域/Research direction
聚焦以子宫内膜异位症、子宫腺肌病、宫腔粘连等为代表的女性生殖障碍相关疾病，致力于从代谢-细胞功能-疾病微环境交叉互作解析其致病机制、开发代谢生物标志物、发现代谢干预新靶点，推动生殖障碍相关疾病精准诊疗。
招生信息/Enrollment information
招生院系：基础医学院
一级学科：基础医学
二级学科：细胞生物学
招生类型：学术型硕士
荣誉奖励/Honors & Awards
山东大学青年学者未来计划
代表性论文/Representative publications
1. Zhong Z#, Wang S, Ren Q, Jiao X, Xu L, Dong X, Li N, Guan H, Chu R, Yuan M, Liu J, Du Y, Wei K*, Yan L*, Wang G*. Stromal cell-derived itaconate promotes endometriosis via macrophage NRF2 and lysosomal pH modulation. Redox Biol. 2026 May; 92:104101.
2. Tong S#, Zhu T, Liang S, Cui Y, Ma Y, Zhang X, Bian Y, Wei K*, Wu S*, Ma J*. Targeting macrophage glycogen metabolism attenuates ulcerative colitis by suppressing IL-1β production through UDPG-P2Y14 signaling. Mol Med. 2026 Feb 4;32(1):15.
3. Wei K#, Tang L#, Zhang X#, Liu S, Tong S, Bian Y, Ma Y, Zhu T, Xiao J, Lin Q, Zhang R, Lv J, Zhang H, Tang K, Wu S, Ma J*, Huang B*. Lithium carbonate induces myofibroblast necroptosis to reverse pulmonary fibrosis. Immun. Inflamm. 1, 3 (2025).
4. Wei K#, Zhang H#, Yang S, Cui Y, Zhang B, Liu J, Tang L, Tan Y, Liu S, Chen S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J*, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther. 2023 Jan 20;8(1):22.
5. Ma J#, Wei K#, Liu J#, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B*. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.
6. Ma J#, Wei K#, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B*. Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells. Cancer Immunol Res. 2018 Sep;6(9):1057-1068.
7. Wu W#, Liu S#, Ren H, Rao Y, Nie J, Wei K*, Jiang X*. Unveiling the oncogenic role of SLC25A13: a multi-omics pan-cancer analysis reveals its impact on glioma progression. Cancer Cell Int. 2025 Mar 3;25(1):76.
8. Wei Z#, Liu J, Wang N*, Wei K*. Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk. Environ Res. 2024 Dec 15;263(Pt 2):120092.
9. Ma J#, Tang L#, Tan Y#, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K, Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Mar;25(3):552-561.
10. Zhang H#, Liu J#, Yang Z#, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B*. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Aug 18;82(16):3077-3088.e6.
