姓名：张传鑫
邮箱：zhangchuan_xin@163.com
个人主页：https://faculty.sdu.edu.cn/zhangchuanxin1234/zh_CN/index.htm
个人简介/Personal resume
张传鑫，山东济南人，副研究员、硕士生导师。首届国家自然科学基金青年学生基础研究项目（博士研究生）获得者。主要研究方向为人类早期胚胎发育的表观遗传调控机制与辅助生殖技术的优化，以第一/通讯作者在Science、Nature Genetics、Nat Struct Mol Biol、Nature communications、Science Advances等杂志发表SCI论文10余篇，授权国家发明专利1件，并实现转化。研究成果先后入选“中国生命科学十大进展”、“中国2022年度重要医学进展”、“首届山东好成果”等。荣获第三届张丽珠生殖医学青年创新奖，现任山东省医学会医学教育分会科普学组委员。
研究领域/Research direction
1. 人类早期胚胎发育的表观遗传调控机制研究
2. 辅助生殖技术对早期胚胎发育的影响及机制研究
招生信息/Enrollment information
招生院系：基础医学院
一级学科：基础医学
二级学科：细胞生物学
招生类型：学术型硕士
荣誉奖励/Honors & Awards
2022年度 中国生命科学十大进展
中国2022年度重要医学进展
首届山东好成果
首届国家自然科学基金青年学生基础研究项目（博士研究生）
第三届张丽珠生殖医学青年创新奖
代表性论文/Representative publications
1.Zou Z#, Zhang C#, Wang Q#, Hou Z#, Xiong Z, Kong F, Wang Q, Song J, Liu B, Liu B, Wang L, Lai F, Fan Q, Tao W, Zhao S, Ma X, Li M, Wu K, Zhao H*, Chen ZJ*, Xie W*. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science. 2022 Oct 7;378(6615):abo7923.
2.Wang Q#, Zhang C#, Dang Y, Sun J, Zou Z, Li C, Ma S, Li Z, Liu H, Ma X, Yang Z, Wang L, Wu K, Chen ZJ*, Xie W*, Zhao H*. Maternal factor OTX2 regulates human embryonic genome activation and early development. Nature Genetics. 2025 Nov;57(11):2772-2784.
3.Zhang C#, Tian H#, Yin X#, Dong X, Wang N, Zhang Y, Wang J, Song J, Li C, Chen ZJ, Liu B*, Wu K*. Crosstalk between H3K4me3 and oxidative stress is a potential target for the improvement of ART-derived embryos. Nature Communications. 2025 Dec 16.
4.Zhu S#, Xie P#, Xu Z#, Pan Q#, Zhang C#, Zhang Y#, Si S, …Wu K*, Xiong B*, Hu P*, Luo Z*, Lin C*. Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage. Nature Structural & Molecular Biology. 2025 Feb;32(2):381-392.
5.Li M#, Huang T#, Li M#, Zhang C#, Yu X, Yin Y, Liu C, Wang X, Feng H, Zhang T, Liu M, Han C, Lu G, Li W, Ma J, Chen Z, Liu H*, Liu K*.The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. Science Advances. 2019 Aug 14;5(8): eaax1101.
6.Song J#, Zhang Y#, Yin X, Dong X, Tian H, You W, Liu B, Wu K, Zhang C*. Proteomic and metabolomic reveals abnormalities in metabolic processes, epigenetic modifications, oxidative stress, embryonic aneuploidy and implantation in mouse blastocysts derived from in vitro fertilization. Journal of Ovarian Research. 2025 Dec 3.
7.Zhang C#, Yin X#, Dong X#, Shi M, Xu Y, Gao J, Wang J, Song J, Liu B, Wu K*. 2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton. Ecotoxicology and Environmental Safety. 2024 Mar 1;272:116105.
8.Zhang C#, Dong X#, Yin X#, Yuan X, Wang J, Song J, Hou Z, Li C, Wu K*. Developmental toxicity of 2-bromoacetamide on peri- and early post-implantation mouse embryos in vitro. Ecotoxicology and Environmental Safety. 2023 Mar 1;252:114612.
9.Zhang C, Dong X, Yuan X, Song J, Wang J, Liu B, Wu K*. Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes. Journal of Ovarian Research. 2022 Oct 14;15(1):112.
10.Zhang C#, Dong X#, Yuan X, Song J, Wang J, Yin X, Hou Z, Li C, Ma S, Chen ZJ, Wu K*. Post-ovulatory aging affects mitochondria, spindle and protein metabolism in mouse oocytes. Reproduction. 2023 Nov 10;166(6):473-484.
