姓名：卢绪坤
邮箱：luxukun@sdu.edu.cn; luxukun66@126.com
个人主页：https://faculty.sdu.edu.cn/luxukun
个人简介/Personal resume
卢绪坤，基础医学博士，山东大学妇儿与生殖健康研究院副研究员，山东大学附属生殖医院研究员，硕士研究生导师。博士毕业于中国科学院动物研究所（导师：李磊研究员），随后在清华大学开展博士后研究（合作导师：颉伟教授）。课题组主要利用小鼠和人的胚胎、胚胎干细胞以及基于干细胞的胚胎模型（SCBEMs）等体系，采用干湿实验相结合的方式，研究配子发生和早期胚胎发育的表观遗传和转录调控，探索人类生殖和发育相关疾病的致病机制。在国际主流学术期刊发表SCI论文30余篇，总引超过1450次（Google Scholar）。其中以第一作者/通讯作者（含共同）在Nature Cell Biology, Nature Structural & Molecular Biology，Science Advances，Nature Communications, eLife等杂志发表研究论文10余篇。承担国家重点研发计划和山东省自然科学基金面上项目。任齐鲁医学院青年人才联盟委员。
研究领域/Research direction
1. 早期胚胎发育的表观遗传和转录调控
2. 胚胎发育异常与生殖相关疾病的致病机制
招生信息/Enrollment information
1. 一级学科：基础医学 / 生物学
2. 二级学科：细胞生物学 / 生物化学与分子生物学 / 发育生物学
3. 学科方向：生殖发育的表观遗传和转录调控
荣誉奖励/Honors & Awards
张丽珠生殖医学青年创新奖
代表性论文/Representative publications
*第一作者，#通讯作者
1. Xukun Lu*#, Lijuan Wang*, Bofeng Liu, Xiaoyu Hu, Zhengmao Wang, Ling Liu, Guang Yu, Lijun Dong, Feng Kong, Qiang Fan, Yu Zhang#, Wei Xie#. Reprogramming of H3K36me2 guides lineage-specific post-implantation de novo DNA methylation. Nature Cell Biology, 27, 2128–2142, 2025.
2. Panpan Shi*, Xukun Lu*, Kairang Jin, Linlin Liu, Guoxing Yin, Wenying Wang, Jiao Yang, Lijuan Wang, Lijun Dong, Wei Xie#, Lin Liu#. USP17L promotes the 2-cell-like program through deubiquitination of H2AK119ub1 and ZSCAN4. Nature Communications, 16, 7071, 2025.
3. Chengpeng Xu*, Dandan Qin*, Xukun Lu*, Qianqian Qi*, Yu Wu, Qizhi Wang, Zhuo Han, Xiaoqing Nie, Yongmei Jiang, Dong Deng#, Wei Xie#, Zheng Gao#, Lei Li#. The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1. Nature Structural & Molecular Biology, 32, 1358-1372, 2025.
4. Wenbo Liu*#, Xukun Lu*, Zheng-Hui Zhao*, Ruibao Su*, Qian-Nan Li, Yue Xue, Zheng Gao, Si-Min Sun, Wen-Long Lei, Lei Li, Geng An, Hanyan Liu, Zhiming Han, Ying-Chun Ouyang, Yi Hou, Zhen-Bo Wang#, Qing-Yuan Sun#, Jianqiao Liu#. SRSF10 is essential for progenitor spermatogonia expansion by regulating alternative splicing. eLife, 11, e78211, 2022.
5. Tie-Gang Meng*, Wen-Long Lei*, Xukun Lu*, Xiao-Yu Liu*, Xue-Shan Ma, Xiao-Qing Nie, Zheng-Hui Zhao, Qian-Nan Li, Lin Huang, Yi Hou, Ying-Chun Ouyang, Lei Li, Tie-Shan Tang, Heide Schatten, Wei Xie, Shao-Rong Gao, Xiang-Hong Ou#, Zhen-Bo Wang#, Qing-Yuan Sun#. Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis. International Journal of Biological Sciences, 18, 4513–4531, 2022.
6. Xukun Lu*, Yu Zhang*, Lijuan Wang*, Leyun Wang*, Huili Wang, Qianhua Xu, Yunlong Xiang, Chaolei Chen, Feng Kong, Weikun Xia, Zili Lin, Sinan Ma, Ling Liu, Xiangguo Wang, Hemin Ni, Wei Li#, Yong Guo#, Wei Xie#. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances, 7, eabi6178, 2021.
7. 卢绪坤*，李元元，颉伟#. 哺乳动物早期胚胎发育中表观遗传信息的传递和重编程. 中国细胞生物学学报, 41, 822-833, 2019.
8. Tie-Gang Meng*, Xukun Lu*, Lei Guo*, Guan-Mei Hou, Xue-Shan Ma, Qian-Nan Li, Lin Huang, Li-Hua Fan, Zheng-Hui Zhao, Xiang-Hong Ou, Ying-Chun OuYang, Heide Schatten, Lei Li, Zhen-Bo Wang#, Qing-Yuan Sun#. Mettl14 is required for mouse post-implantation development by facilitating epiblast maturation. The FASEB Journal, 33, 1179-1187, 2019.
9. Xukun Lu*, Zhen-Ao Zhao, Xiaoqing Wang, Xiaoxin Zhang, Yanhua Zhai, Wenbo Deng, Zhaohong Yi#, Lei Li#. Whole-transcriptome splicing profiling of E7. 5 mouse primary germ layers reveals frequent alternative promoter usage during mouse early embryogenesis. Biology Open, 7, bio032508, 2018.
10. Xukun Lu*, Zheng Gao*, Dandan Qin, Lei Li#. A maternal functional module in the mammalian oocyte-to-embryo transition. Trends in molecular medicine, 23, 1014-1023, 2017.
11. Lei Li#*, Xukun Lu, Jurrien Dean#. The maternal to zygotic transition in mammals. Molecular aspects of medicine, 34, 919-938, 2013.
欢迎对发育生物学、表观遗传学及生殖医学研究感兴趣的同学加入。
