姓名：黄涛
邮箱：htao1568@sdu.edu.cn
个人主页：http://faculty.sdu.edu.cn/huangtao123/zh_CN/index.htm
个人简介/Personal resume
黄涛 理学博士，研究员，硕士研究生导师，省级青年专家。
山东大学妇儿与生殖健康研究院 重大项目办公室主任。
从事生殖相关疾病的基础与临床研究，重点关注发育与疾病的遗传与表观遗传调控。以第一/通讯作者（含共同）在Adv Sci（2篇）、Sci Adv、Genome Biol、Sci Bullet、Cell death differ、Sci China Life Sci、Nucleic Acids Res（3篇）、Elife、J Genet Genomics、iScience、J Transl Med等期刊发表论文20余篇。主持国家自然科学基金面上项目1项和横向课题1项，课题骨干身份承担国家自然科学基金重大项目1项，重点研发计划项目2项，参与国家自然科学基金重大项目1项，面上项目2项。荣获山东省医学科技进步一等奖（2025年度，2/7）。现任中国医师协会医学遗传学分会委员、中国非公立医疗机构协会男性生殖与性医学专业委员会委员、山东省研究型医院协会杰出青年学者分会委员、山东省医学会医学细胞生物学分会科普学组委员、山东省医学会健康教育与健康促进学组委员。全国研究生教育评估监测专家库专家，Military Medical Research/Phenomics期刊青年编委。
研究领域/Research direction
1. 基础研究：利用分子生物学、细胞生物学、动物模型和合作开发的多种微量组学技术等研究高等生物配子发生和胚胎发育的分子调控机制。科研方向包括可变剪接调控原始生殖细胞分化的分子机制、减数分裂同源重组的遗传与表观遗传调控，精源性疾病的分子调控机制等，重点关注表观遗传尤其是组蛋白修饰及其识别分子、核心转录因子等在以上发育过程中的动态变化及分子调控机制。
2. 转化及应用研究：无创诊断技术研发及应用，重点关注基于血浆、精浆、尿液等蛋白质、代谢物和游离DNA/RNA的序列信息及其修饰信息的诊断方法研发及其临床推广应用。
招生信息/Enrollment information
招生学科（一级和二级学科）：
一级学科：基础医学/理学
二级学科：基础医学/生物学
学科方向：细胞生物学/生物化学与分子生物学/发育生物学
荣誉奖励/Honors & Awards
省级青年专家（2024年）、山东省医学科技进步一等奖（2/7，2025年）
山东省研究生优秀成果奖（指导教师，2025年）
第十二届全国大学生医学创新大赛暨“一带一路”国际竞赛（山东大学校赛）优秀成果奖二等奖（指导教师，2026年）
山东大学医学创新大赛优秀奖（指导教师，2025年）
山东大学妇儿与生殖健康研究院研究生优秀成果指导奖（2025年）
山东大学妇儿与生殖健康研究院优秀实验教学指导教师（2024年）
代表性论文/Representative publications
1. Shenli Yuan#, Shiyu Wang#, Ziyou Bao#, Ziqi Wang#, Kang Shangguan, Yelian Yan, Yajun Shi, Xu Feng, Chengqi Huang, Mengrui Fang, Caoling Xu, Jianqiang Bao, Han Zhao, Shigang Zhao, Hongbin Liu, Zi-Jiang Chen*, Tao Huang*. Dual histone methylation reader ZCWPW2 links histone methylation to initiation of meiotic recombination. 2026. In submission.
2. Shiyu Wang#, Tongtong Li#, Yuling Cai#, Kang Shangguan, Ziqi Wang, Chengqi Huang, Yajun Shi, Jing Xin, Qun Zhao, Honghui Zhang, Han Zhao, Yihong Guo*, Hongbin Liu*, Zi-Jiang Chen*, Tao Huang*. CWF19L2 couples pre-mRNA alternative splicing with the maternal-to-zygotic transition to safeguard female fertility. 2026. In submission.
3. Yiduo Wang#, Yu Wang#, Yalin Liang#, Wenlin Fu, Sile Tang, Yelian Yan, Jianfan Wei, Kanghua Zhong, Kang Shangguan, Haiyang Wu, Feng Yi*, Xiaobo Wang*, Tao Huang*, Shenli Yuan*. Sleep deprivation induces temporally staged sperm epigenomic remodeling in mice. 2026. In submission.
4. Qun Zhao, Ziqi Wang, Kang Shangguan, Biyun Liu, Xinyue Wu, Shiyu Wang, Chengqi Huang, Shuhui Ji, Tao Huang*, Hongbin Liu*. PPIH, a component of U4/U6 snRNP, regulates spermiogenesis by alternative splicing. 2026. Under review.
5. Honghui Zhang#, Bohan Yang#, Shiyu Wang#, Huan Zhang#, Wei Su, Changjian Yin, Xiaolei Chen, Yuehong Bian, Shigang Zhao, Zi-Jiang Chen, Han Zhao, Tao Huang*, Qinghua Shi*. Dominant CHK1 Mutations Drive Male Infertility via Pathological Phase Separation and Hyperactivated Checkpoint Signaling. Science China-Life Sciences. 2026. In proof. (JCR一区，IF 9.6. 共同通讯作者)
6. Shenli Yuan#, Yelian Yan#, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang*, Chao Liu*, Tao Huang*, Keliang Wu*. The landscape and regulation of histone crotonylation in mammalian gametes and early embryos. Advanced Science;2026. Apr 3:e75143. (JCR一区，IF 15.6. 共同通讯作者)
7. Shiyu Wang#, Yuling Cai#, Tongtong Li, Yan Wang, Ziyou Bao, Renxue Wang, Junchao Qin, Ziqi Wang,Yining Liu, Zhaojian Liu, Wai-Yee Chan, Xiangfeng Chen, Gang Lu*, Zi-Jiang Chen*, Tao Huang*, and Hongbin Liu*. CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing. Advanced Science; 2024 Jun 18: e2403866. (JCR一区，IF 16.3. 共同通讯作者)
8. Tao Huang#, Xinyue Wu#, Shiyu Wang, Ziyou Bao, Yanling Wan, Ziqi Wang, Mengjing Li, Xiaochen Yu, Yue Lv, Zhaojian Liu, Xiangfeng Chen, Wai-Yee Chan, Fei Gao, Gang Lu*, Zi-Jiang Chen*，Hongbin Liu*. SPIDR is Required for Homologous Recombination During Mammalian Meiosis. Nucleic Acids Research; 2023 May 8;51(8):3855-3868. (JCR一区，IF 19.16. 第一作者)
9. Shenli Yuan#, Tao Huang# *, Ziyou Bao#, Shiyu Wang#, Xinyue Wu#, Jiang Liu*, Hongbin Liu*, Zi-Jiang Chen*. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots. Genome Biology; 2022 Sep 6;23(1):187.（JCR一区，IF 20.36. 共同第一作者和共同通讯作者）
10. Junchao Qin#, Tao Huang#, Zixiang Wang#, Xiyu Zhang, Jing Wang, Qianli Dang, Donghai Cui, Xinyu Wang, Yunjiao Zhai, Ling Zhao, Gang Lu, Changshun Shao, Shiyang Li, Hongbin Liu*, Zhaojian Liu*. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation. Cell Death and Differentiation; 2023 Jan;30(1):184-194. (JCR一区，IF 12.89. 共同第一作者)
11. Shixiong Tian#, Ziqi Wang#, Liting Liu#, Yiling Zhou, Yue Lv, Dongdong Tang, Jiaxiong Wang, Jing Jiang, Huan Wu, Shuyan Tang, Guanxiong Wang, Hao Geng, Fangbiao Tao, Hongbin Liu, Xiaojin He, Feng Zhang, Jinsong Li, Li Jin, Tao Huang*, Chunyu Liu*, Yunxia Cao*. A homozygous frameshift mutation in ADAD2 cause male infertility with spermatogenic impairments. Journal of Genetics and Genomics; 2023 Jan 3; S1673-8527(22)00284-3. (JCR一区，IF 5.75. 共同通讯作者)
12. Tao Huang#, Shenli Yuan#, Lei Gao, Mengjing Li, Xiaochen Yu, Jianhong Zhan, Yingying Yin, Chao Liu, Chuanxin Zhang, Gang Lu, Wei Li, Jiang Liu*, Zi-Jiang Chen*, and Hongbin Liu*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair. eLife; Vol.9;2020; e53459. (JCR一区，IF 9.05. 第一作者)
13. Tao Huang#, YingyingYin#, ChaoLiu, MengjingLi, XiaochenYu, XiugeWang, HaoboZhang, Tahir Muhammad, FeiGao, WeiLi, Zi-JiangChen*, HongbinLiu*, JinlongMa*. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella. Science Bulletin; Vol.65(10);2020;854-864. (JCR一区，IF11.78. 第一作者)
14. Yongliang Shang#, Tao Huang#, Hongbin Liu, Yanlei Liu, Heng Liang, Xiaoxia Yu, Mengjing Li, Binyuan Zhai, Xiao Yang, Yudong Wei, Guoqiang Wang, Zijiang Chen*, Shunxin Wang*, Liangran Zhang*. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Nucleic Acids Research; Vol.48(12);2020;6624-663. (JCR一区，IF 15.54. 共同第一作者)
15. Miao Li#, Tao Huang#, Meng-Jing Li#, Chuan-Xin Zhang#, Xiao-Chen Yu, Ying-Ying Yin, Chao Liu, Xin Wang, Hai-Wei Feng, Tuo Zhang, Mo-Fang Liu, Chun-Sheng Han, Gang Lu, Wei Li, Jin-Long Ma, Zi-Jiang Chen, Hong-Bin Liu*, Kui Liu*. The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. Science Advances; Vol.5, no.8;2019; eaax1101. (JCR一区，IF 14.09. 共同第一作者)
16. Hongbin Liu#, Tao Huang#, Mengjing Li#, Miao Li, Chuanxin Zhang, Jing Jiang, Xiaochen Yu, Yingying Yin, Fan Zhang, Gang Lu, Meng-Cheng Luo, Liang-Ran Zhang, Jinsong Li, Kui Liu*, Zi-Jiang Chen*. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis. Nucleic Acids Research; Vol.47(11);2019;5670-5683. (JCR一区，IF 11.79. 共同第一作者)
17. Yining Liu, Tongtong Li, Mingze Shi, Yanling Wan, Hanzhen Li, Mingyu Zhang, Ziqi Wang, Shiyu Wang, Yue Lv, Gang Lu, Hongbin Liu, Haobo Zhang*, Tao Huang*. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice. J Transl Med, 2024 Mar 5;22(1):240. (JCR一区，IF 7.4. 最后通讯作者)
18. Ziqi Wang, Tongtong Li, Dongkai Liu, Mengjing Li, Shangming Liu, Xiaochen Yu, Hanzhen Li, Hui Song, Wei Zhao, Zhaojian Liu, Xiangfeng Chen, Yuan Gao, Zi-Jiang Chen*, Tao Huang*, Hongbin Liu*. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis. iScience, 2024 Mar 11;27(4):109456. (JCR一区，IF 5.8.共同通讯作者)
19. Yingying Yin, Wenyu Mu, Xiaochen Yu, Ziqi Wang, Ke Xu, Xinyue Wu, Yuling Cai, Mingyu Zhang, Gang Lu, Wai-Yee Chan, Jinlong Ma, Tao Huang*, Hongbin Liu*. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. International Journal of Molecular Sciences; 2022 Jul 31;23(15):8525. (JCR二区，IF 6.62. 共同通讯作者)
20. Ziqi Wang#, Kailun Fang, Yanling Wan, Yingying Yin, Mengjing Li, Ke Xu, Tongtong Li, Yongzhi Cao, Yue Lv, Gang Lu, Hongbin Liu, Tao Huang*. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. Cells; 2023 Aug 18;12(16):2091. (JCR二区，IF 6.7. 唯一通讯作者)
21. Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang. RAD51 is essential for spermatogenesis and male fertility in mice. Cell Death Discovery; Vol.8(1);2022;118.（JCR二区，IF 5.302，第二位）
22. Fucheng Dong, Xiuge Wang, Tao Huang, Yingying Yin, Sai Xiao, Yanjie Ma, Huafang Wei, Bingbing Wu, Ruidan Zhang, Liying Wang, Xuejiang Guo, Fei Gao, Chao Liu, Hongbin Liu*, Jianguo Zhao*, Wei Li*. CCDC178-mediated cytoskeleton assembly is required for spermiogenesis in mice. Genes Dis. 2023 Sep 29;11(6):101132. （JCR一区，IF 7.2，第三位）
23. Yanling Wan, Shuang Yang, Tongtong Li, Yuling Cai, Xinyue Wu, Mingyu Zhang, Tahir Muhammad, Tao Huang, Yue Lv, Wai-Yee Chan, Gang Lu, Jingxin Li, Qian-Qian Sha, Zi-Jiang Chen, Hongbin Liu. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023 Nov 27;51(21):11652-11667. （JCR 一区，IF 16.6,参与）
24. Yunde Dou#, Rusong Zhao#, Han Wu, Zhiheng Yu, Changjian Yin, Jie Yang, Chaoyan Yang, Xiaohua Luan, Yixiao Cheng, Tao Huang, Yuehong Bian, Shan Han, Yuqing Zhang, Xin Xu, Zi-Jiang Chen, Han Zhao, Shigang Zhao. DENND1A desensitizes granulosa cells to FSH by arresting intracellular FSHR transportation. Sci China Life Sci. 2024 Aug;67(8):1620-1634. （JCR 一区，IF 9.49,参与）
25. Xiaona You, Xi Hu, Zenghui Sun, Wenwen Xu, Lanlan Liu, Tao Huang, Shenli Yuan, Jilong Yin, Hao Wang, Limei Wang, Juncheng Wang, Wei Xu, Zhiyue Zhang, Yingjie Zhang, Yuchen Fan, Fabao Liu. Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis. Cancer Lett. 2025 Mar 1:612:217493. （JCR 一区，IF 11.4,参与）
26. Mengjing Li#, Zhenhai Du#, Hanzhen Li#, Mingyu Zhang, Yining Liu, Fengyu Zhang, Liangjun Hu, Lichuan Gu, Xiangfeng Chen, Tao Huang, Gang Lu, Wai-Yee Chan, Fei Gao, Zi-Jiang Chen*, Wei Xie*, Hongbin Liu*. Nucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis. Nat Commun. 2026 Mar 26. （JCR 一区，IF 17.7,参与）
27. Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou. BRD4 Signaling Maintains the Differentiated State of β Cells. Adv Sci (Weinh). 2025 Sep;12(33):e05659. （JCR 一区，IF 15.6,参与）
