姓名：刘博洋
邮箱：byliu@sdu.edu.cn
个人主页：
https://faculty.sdu.edu.cn/liuboyang/zh_CN/index.htm
https://qlyxjxgl.sdu.edu.cn/jsxx/sddxfsszyy/lby.htm
https://www.sduivf.sdu.edu.cn/info/1030/1290.htm
个人简介/Personal resume
刘博洋，男，内蒙古呼和浩特人，博士、研究员、硕士生导师。山东省泰山学者青年专家，山东省优秀青年科学基金（海外）获得者。2016年毕业于德国哥廷根大学发育生物学专业，获自然科学博士学位。长期从事早期胚胎发育调控机制方面的研究，主要关注人类胚胎发育调控异常导致的妊娠失败和生殖障碍。在国家重点研发计划项目、国家自然科学基金、山东省重点研发计划项目及山东省自然科学基金等的资助下，在Nat Commun、Current Biology、eLife、PLoS Genet等学术期刊发表SCI论文30余篇，参编中外专著2部。受邀担任BMC Pregnancy Childb、Scientific Reports等期刊编委，兼任山东省医学会医学科管分会学组委员，山东省医学会健康传播分会学组委员，山东省青年科学家协会会员，山东省高层次人才发展促进会会员。
研究领域/Research direction
1. 早期胚胎发育的代谢调控规律
2. 围植入期胚胎细胞谱系分化调控机制
3. 胚胎发育异常与生殖障碍
招生信息/Enrollment information
招生院系：基础医学院
一级学科：基础医学
二级学科：细胞生物学
招生类型：学术型硕士
荣誉奖励/Honors & Awards
山东省泰山学者青年专家
山东省优秀青年科学基金（海外）
山东大学青年学者未来计划
山东省科普创作大赛三等奖
山东大学青年临床教师教学比赛三等奖
山东大学妇儿与生殖健康研究院优秀青年指导教师
代表性论文/Representative publications
1. T Deng#, Y Zhang#, H Tian, Y Xu, C Zhang, J Wang, J Gao, K Wu*, B Liu*. Maternal LDHB Safeguards Redox Balance and Developmental Competence During Preimplantation Embryo Cleavage. FASEB Journal, 2026, 40(10), e71888.
2. C Zhang#, H Tian#, X Yin#, X Dong, N Wang, Y Zhang, J Wang, J Song, C Li, ZJ Chen, B Liu*, K Wu*. Crosstalk between H3K4me3 and oxidative stress is potential target for the improvement of ART-derived embryos. Nature Communications, 2026, 17(852).
3. X Yuan#, W Zhong#, C Zhang, X Dong, X Yin, T Deng, J Song, J Wang, Y Xu, H Liu, K Wu, B Liu*. Astaxanthin promotes in vitro maturation of mouse oocytes by regulating mitochondrial functions and protein homeostasis. Biol Reprod, 2025.
4. M Shi#, Y Huai#, T Deng#, C Zhang, J Song, J Wang, Y Zhang, ZJ Chen, H Zhao, K Wu*, B Liu*. SHMT2 is essential for mammalian pre-implantation embryonic development through de novo biosynthesis of nucleotide metabolites. Mol Ther Nucl Acids, 2025, 36 (2) 102499.
5. J Gao#, J Wang#, S Liu, J Song, C Zhang, B Liu*, K Wu*. The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision. eLife, 2025, 13: RP100730.
6. X Chen, H Zhao, J Lv, Y Dong, M Zhao, X Sui, R Cui, B Liu*, K Wu*. Calcium Ionophore Improves Embryonic Development and Clinical Outcomes in Patients with Previous Developmental Problems in ICSI Cycles. BMC Pregnancy Childb, 2022, 22(894).
7. Z Zou#, C Zhang#, Q Wang#, Z Hou#, Z Xiong, F Kong, Q Wang, J Song, B Liu, B Liu, L Wang, F Lai, Q Fan, W Tao, S Zhao, X Ma, M Li, K Wu, H Zhao*, ZJ Chen*, W Xie*. Translatome and Transcriptome Co-profiling Reveals a Role of TPRXs in Human Zygotic Genome Activation. Science, 2022, 378(6615).
8. B Liu, H Zhao, K Wu, J Großhans*. Temporal Gradients Controlling Embryonic Cell Cycle. Biology-Basel, 2021, 10(6): 513.
9. B Liu, I Gregor, H-A Müller, J Großhans*. Fluorescence Fluctuation Analysis Reveals PpV Dependent Cdc25 Protein Dynamics in Living Embryos. PLoS Genetics, 2020, 16(4).
10. B Liu#, F Winkler#, M Herde, C-P Witte, J Großhans*. A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control. Current Biology, 2019, 29(7): 1187-1192.
11. B Liu, J Großhans*. The Role of dNTP Metabolites in Control of the Embryonic Cell Cycle. Cell Cycle, 2019, 18(21): 2817-2827.
12. B Liu, HW Sung, J Großhans*. Multiple Functions of the Essential Gene PpV in Drosophila Early Development. G3-Genes Genomes Genetics, 2019, 9(11): 3583-3593.
13. B Liu, J Großhans*. Link of Zygotic Genome Activation and Cell Cycle Control. Meth Mol Biol, Humana Press, 2017, 1605: 11–30.
14. B Liu#, R Yang#, J Li, L Zhang, J Liu, C Lu, C Lian, Z Li, Y Zhang, L Zhang, Z Zhao*. Construction of fat1 Gene Expression Vector and Its Catalysis Efficiency in Bovine Fetal Fibroblast Cells. Asian-Aust J Anim Sci, 2012, 25(5): 621-628.
15. C Lian#, B Sun#, S Niu, R Yang, B Liu, C Lu, J Meng, Z Qiu, L Zhang*, Z Zhao*. A Comparative Profile of the MicroRNA Transcriptome in Immature and Mature Porcine Testes using Solexa Deep Sequencing. FEBS J, 2012, 279(6): 964-75.
