姓名：刘博洋
邮箱：byliu@sdu.edu.cn
个人主页：
https://faculty.sdu.edu.cn/liuboyang/zh_CN/index.htm
个人简介/Personal resume
刘博洋，男，内蒙古呼和浩特人，博士，副研究员，硕士生导师。山东省泰山学者青年专家，山东省优秀青年科学基金（海外）获得者。2016年毕业于德国哥廷根大学发育生物学专业，获自然科学博士学位。长期从事早期胚胎发育调控机制方面的研究，主要关注人类胚胎发育调控异常导致的妊娠失败和生殖障碍。累计发表SCI论文10余篇，目前承担国家重点研发计划项目1项、国家自然科学基金青年项目1项、山东省自然科学基金青年项目1项。
研究领域/Research direction
1. 早期胚胎发育的代谢调控规律
2. 围植入期胚胎细胞谱系分化调控机制
3. 胚胎发育异常与生殖障碍
招生信息/Enrollment information
招生院系：基础医学院
一级学科：生物学
二级学科：细胞生物学
招生类型：学术型硕士
荣誉奖励/Honors & Awards
山东省泰山学者青年专家
山东省优秀青年科学基金（海外）
山东大学青年学者未来计划
代表性论文/Representative publications
1. S Zhao, Y Cui, S Guo, B Liu, Y Bian, S Zhao, ZJ Chen, H Zhao*. Novel Variants of ACTL7A and PLCZ1 are Associated with Male Infertility and Total Fertilization Failure. Clinical Genetics, 2023.
2. X Chen, H Zhao, J Lv, Y Dong, M Zhao, X Sui, R Cui, B Liu*, K Wu*. Calcium Ionophore Improves Embryonic Development and Clinical Outcomes in Patients with Previous Developmental Problems in ICSI Cycles. BMC Pregnancy Childb, 2022, 22(894).
3. C Zhang, X Dong, X Yuan, J Song, J Wang, B Liu, K Wu*. Proteomic Analysis Implicates that Postovulatory Aging Leads to Aberrant Gene Expression, Biosynthesis, RNA metabolism and Cell Cycle in Mouse Oocytes. J Ovarian Res, 2022, 15(112).
4. Z Zou#, C Zhang#, Q Wang#, Z Hou#, Z Xiong, F Kong, Q Wang, J Song, B Liu, B Liu, L Wang, F Lai, Q Fan, W Tao, S Zhao, X Ma, M Li, K Wu, H Zhao*, ZJ Chen*, W Xie*. Translatome and Transcriptome Co-profiling Reveals a Role of TPRXs in Human Zygotic Genome Activation. Science, 2022, 378(6615).
5. J Song#, J Zhang#, X Yuan, B Liu, W Tao, C Zhang, K Wu*. Functional Substitution of Zona Pellucida with Modified Sodium Hyaluronate Gel in Human Embryos. J Assist Reprod Genet, 2022, 39, 2669-2676.
6. B Liu, H Zhao, K Wu, J Großhans*. Temporal Gradients Controlling Embryonic Cell Cycle. Biology-Basel, 2021, 10(6): 513.
7. B Liu, I Gregor, H-A Müller, J Großhans*. Fluorescence Fluctuation Analysis Reveals PpV Dependent Cdc25 Protein Dynamics in Living Embryos. PLoS Genetics, 2020, 16(4).
8. B Liu#, F Winkler#, M Herde, C-P Witte, J Großhans*. A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control. Current Biology, 2019, 29(7): 1187-1192.
9. B Liu, J Großhans*. The Role of dNTP Metabolites in Control of the Embryonic Cell Cycle. Cell Cycle, 2019, 18(21): 2817-2827.
10. B Liu, HW Sung, J Großhans*. Multiple Functions of the Essential Gene PpV in Drosophila Early Development. G3-Genes Genomes Genetics, 2019, 9(11): 3583-3593.
11. B Liu, J Großhans*. Link of Zygotic Genome Activation and Cell Cycle Control. Meth Mol Biol, Humana Press, 2017, 1605: 11–30.
12. B Liu#, R Yang#, J Li, L Zhang, J Liu, C Lu, C Lian, Z Li, Y Zhang, L Zhang, Z Zhao*. Construction of fat1 Gene Expression Vector and Its Catalysis Efficiency in Bovine Fetal Fibroblast Cells. Asian-Aust J Anim Sci, 2012, 25(5): 621-628.
13. C Lian#, B Sun#, S Niu, R Yang, B Liu, C Lu, J Meng, Z Qiu, L Zhang*, Z Zhao*. A Comparative Profile of the MicroRNA Transcriptome in Immature and Mature Porcine Testes using Solexa Deep Sequencing. FEBS J, 2012, 279(6): 964-75.
