山东大学 | 齐鲁医学院

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邮箱:fujiang@sdu.edu.cn








个人简介/Personal resume

山东医科大学临床医学学士、外科学硕士,新加坡国立大学博士,美国罗彻斯特大学博士后。山东大学生殖医学研究中心研究员。

研究领域/Research direction

本课题组研究---细胞分化发育及其微环境

主要研究课题

1.WNT信号在胚层形成、器官发生组织稳态的作用机制   

2. 细胞微环境神经内分泌因素对生殖细胞发育的调控作用


招生信息/Enrollment information

招生学科(一级和二级学科):临床医学妇产科学

学科方向:生殖医学


荣誉奖励/Honors & Awards


代表性论文/Representative publications

1. Shi J, Niu Q, Gao Q, Fu J, Ma J. Initiation of oogenesis and meiosis in the fetal ovary depends on Dennd1a-mediated production of Wnt5a and retinoic acid from the somatic niches. Front Biosci (Landmark Ed). 2021 Dec 30;26(12):1513-1524. doi: 10.52586/5045.

2. Niu Q, Shi J, Gao Q, Fu J. WNT5A Enhances LH-Mediated Expression of HAS2 in Granulosa Cells. Reprod Sci. 2022 May;29(5):1618-1629. doi: 10.1007/s43032-021-00736-7. Epub 2021 Sep 20.

3. 牛群,石婧婧,符江. WNT5A基因对卵巢颗粒细胞胰岛素反应性和胰岛素抵抗的调控作用. 山东大学学报(医学版). 2021, 59(06):57-63

4. Shi J, Gao Q, Cao Y, Fu J. Dennd1a, a susceptibility gene for polycystic ovary syndrome, is essential for mouse embryogenesis. Dev Dyn. 2019 May;248(5):351-362. doi: 10.1002/dvdy.28. Epub 2019 Apr 2.

5. Liu X, Gao Q, Zhao N, Zhang X, Cui W, Sun J, Fu J, Hao J. Sohlh1 suppresses glioblastoma cell proliferation, migration, and invasion by inhibition of Wnt/β-catenin signaling. Mol Carcinog. 2018 Apr;57(4):494-502. doi: 10.1002/mc.22774. Epub 2018 Jan 5.

6. Das S, Yu S, Sakamori R, Vedula P, Feng Q, Flores J, Hoffman A, Fu J, Stypulkowski E, Rodriguez A, Dobrowolski R, Harada A, Hsu W, Bonder EM, Verzi MP, Gao N. Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche. Development. 2015 Jun 15;142(12):2147-62. doi: 10.1242/dev.121046. Epub 2015 May 26.

7. Fu J, Yu HM, Chiu SY, Mirando AJ, Maruyama EO, Cheng JG, Hsu W. Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration. PLoS Genet. 2014 Oct 9;10(10):e1004579. doi: 10.1371/journal.pgen.1004579. eCollection 2014 Oct.

8. Fu J, Hsu W. Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis. J Invest Dermatol. 2013 Apr;133(4):890-8. doi: 10.1038/jid.2012.407. Epub 2012 Nov 29.

9. Fu J, Ivy Yu HM, Maruyama T, Mirando AJ, Hsu W. Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn. 2011 Feb;240(2):365-71. doi: 10.1002/dvdy.22541. Epub 2011 Jan 11.

10. Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W. Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603. doi: 10.1073/pnas.0904894106. Epub 2009 Oct 19.



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