邮箱：zsg0108@126.com
个人主页：https://faculty.sdu.edu.cn/zhaoshigang/
个人简介/Personal resume
中共党员，教授，副主任医师，博士生导师，国家“四青”人才，山东省优青，山东大学杰出中青年学者。师从于我国著名生殖医学专家陈子江院士，主要从事以肥胖和多囊卵巢综合征为代表女性重大生殖内分泌代谢性疾病的病因学及临床分型防治研究，致力于探索生殖与代谢的交互作用关系。在国家重点研发计划青年科学家项目（首席）及子课题（2 项）、国家自然科学基金（3项）、山东省重点研发计划及自然科学基金、中国博士后项目（面上和特别）等的资助下，以通讯作者在Cell Metabolism、Signal Transduction and Targeted Therapy、Nature Human Behaviour、Nature Communications等杂志发表SCI论文30余篇。兼任中国妇幼保健协会临床质谱精准应用与生殖健康专业委员会常务委员，中国毒理学会发育毒理与发育源性疾病防控专业委员会常务委员，中国健康管理协会妇幼健康管理分会理事，中国细胞生物学学会生殖细胞生物学分会委员，山东省医学会肥胖防治多学科联合委员会副主任委员，山东省医学会生殖医学分会委员，山东省研究型医院协会生殖医学研究分会委员，济南市科协创新智库专家，山东大学附属生殖医院学术委员会秘书，齐鲁医学院青年人才联盟副主席，Exploration期刊青年学术顾问，iMeta、Fundamental Research（基金委主办期刊）、 Genomics, Proteomics & Bioinformatics（中科院主管）、Phenomics等期刊青年编委。
研究领域/Research direction
本课题组研究以肥胖和多囊卵巢综合征为代表的女性重大生殖内分泌代谢性疾病的病因学及临床分型诊疗。
主要研究课题：
1. 基于前沿组学技术的女性生殖代谢性疾病的可解释人工智能分型
2. 女性生殖内分泌代谢性疾病不同亚型对母婴健康的影响与机制研究
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学，妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
国家“四青”人才
山东省自然科学优秀青年基金
中华医学科技--青年科技奖
山东省医学会--青年科技奖
全国大学生生命科学竞赛国家级二等奖省级一等奖-指导教师
全国大学生医学创新大赛暨“一带一路”国际竞赛校优秀成果奖-指导教师
山东大学基础医学创新研究暨实验设计大赛优秀成果奖-指导教师
山东大学附属生殖医院优秀青年指导教师
代表性论文/Representative publications
1. Liu Y#, Dong Y#, Jiang Y, Han S, Liu X, Xu X, Zhu A, Zhao Z, Gao Y, Zou Y, Zhang C, Bian Y, Zhang Y, Liu J, Zhao S*, Zhao H*, Chen ZJ. Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming. Cell Metab. 2025 Apr 1;37(4):920-935.e6. doi:10.1016/j.cmet.2025.01.014.
2. Qin L#, Sun T#, Li X#, Zhao S#,*, Liu Z, Zhang C, Jin C, Xu Y, Gao X, Cao Y, Wang J, Han T, Yan L, Song J, Zhang F, Liu F, Zhang Y, Huang Y, Song Y, Liu Y, Zhang J, Zhang X, Yao Z, Chen H, Zhang Z, Zhao S, Feng Y, Zhang YN, Yu Q, Cao F, Zhao L, Xie L, Geng L*, Feng Q*, Zhao H*, Chen ZJ*. Population-level analyses identify host and environmental variables influencing the vaginal microbiome. Signal Transduct Target Ther. 2025 Feb 19;10(1):64. doi: 10.1038/s41392-025-02152-8.
3. Yang Z#, Feng G#, Gao X#, Yan X, Li Y, Wang Y, Li S, Jiang Y, Zhao S*, Zhao H*, Chen ZJ*. Maternal adiposity and perinatal and offspring outcomes: an umbrella review. Nat Hum Behav. 2024 Oct 11. doi: 10.1038/s41562-024-01994-6.
4. Zhang YQ#, Han S#, Liu CC, Zheng YW, Li H, Gao F, Bian YH, Liu X, Liu HB, Hu SR, Li YX, Chen ZJ *, Zhao S*, Zhao H*. THADA Inhibition Protects against Type 2 Diabetes Mellitus by Improving Pancreatic 2 β-cell Function and Preserving β-cell Mass. Nat Commun. 2023 Feb 23;14(1):1020. doi: 10.1038/s41467-023-36680-0.
5. Xu H#, Chi Y#, Yin C#, Li C#, Chen Y, Liu Z, Liu X, Xie H, Chen ZJ, Zhao H, Wu K, Zhao S*, Xing D*. Three-dimensional genome structures of single mammalian sperm. Nat Commun. 2025 Apr 23;16(1):3805. doi: 10.1038/s41467-025-59055-z.
6. Li S#, Huang X#, Zhao H*, Liu S*, Zhao S*. Bariatric Surgery Impact on Women with Polycystic Ovary Syndrome: A Prospective Cohort Study. Research (Wash D C). 2025 Apr 9;8:0664. doi: 10.34133/research.0664.
7. Yan X#, Yang Z#, Zhao H#, Feng G, Li S, Li Y, Sun Y, Ma J, Zhao H, Gao X*, Zhao S*. Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models. BMC Med. 2025 May 19;23(1):289. doi: 10.1186/s12916-025-04120-z.
8. Jiang Y#, Gao X#, Liu Y, Yan X, Shi H, Zhao R, Chen ZJ*, Gao F*, Zhao H*, Zhao S*. Cellular atlases of ovarian microenvironment alterations by diet and genetically-induced obesity. Sci China Life Sci. 2023 Sep 15. doi:
10.1007/s11427-023-2360-3.
9. Dou Y#, Zhao R#, Wu H, Yu Z, Yin C, Yang J, Yang C, Luan X, Cheng Y, Huang T, Bian Y, Han S, Zhang Y, Xu X, Chen ZJ, Zhao H*, Zhao S*. DENND1A Desensitizes Granulosa Cells to FSH by Arresting Intracellular FSHR Transportation. Sci China Life Sci. 2024 Aug;67(8):1620-1634. doi: 10.1007/s11427-023-2438-4.
10. Zhang L#, Liu X#, Zhang Y#, Qin L#, Pan S, Yan X, Dong S, Feng Z, Fan SJ, Zhao R, Gao X, Zhao S*, Shi J*, Zhao H*, Zhang Y*, Chen ZJ. Peripheral blood RNA modifications as a novel diagnostic signature for polycystic ovary syndrome. Sci China Life Sci. 2025 Jun 3. doi: 10.1007/s11427-024-2913-7.
11. Dong Y, Zhao S, Zhao H. ZP2: the precision regulator of egg coat architecture during fertilization. Sci China Life Sci. 2024 Aug;67(8):1779-1780. doi: 10.1007/s11427-024-2611-3. Epub 2024 May 24.
12. Gao X#, Wang Y#, Wang Y, Yang Z, Yan X, Li S, Jiang Y, Li Y, Zhao S*, Zhao H, Chen ZJ. No Association of Polycystic Ovary Syndrome with Pancreatic Cancer: A Mendelian Randomization Study. Phenomics. 2024 Sep 19;4(5):522-524. doi:10.1007/s43657-024-00156-y.
13. Zhang H#, Cui Y#, Yang B, Hou Z, Zhang M, Su W, Chen T, Bian Y, Li M, Chen ZJ, Zhao H, Zhao S*, Wu K*. CHK1 controls zygote pronuclear envelope breakdown by regulating F-actin through interacting with MICAL3. EMBO Rep. 2024 Oct 2. doi: 10.1038/s44319-024-00267-7.
14. Wang Y#, Gao X#, Yang Z, Yan X, He X, Guo T, Zhao S*, Zhao H*, Chen ZJ. Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guideline. Hum Reprod. 2023 Nov 20;38(Supplement_2):ii69-ii79. doi: 10.1093/humrep/dead191.
15. Liu Z, Zheng Y, Wang B, Li J, Qin L, Li X, Liu X, Bian Y, Chen Z, Zhao H, Zhao S*. The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study. Fertil Steril. 2023 Jan;119(1):47-55. doi:10.1016/j.fertnstert.2022.10.015.
16. Zhao S, Chen T, Yu M, Bian Y, Cao Y, Ning Y, Su S, Zhang J, Zhao S*. Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertil Steril. 2019 Mar;111(3):519-526. doi:10.1016/j.fertnstert.2018.11.018.
17. Zhang Y#, Jiang Y#*, Yu Y, Feng G, Zhao Z, Zhang W, Li S, Li Y, Yang Z, Yan X, Gao X, Chen ZJ, Zhao H*, Zhao S*. snRNA-seq of human ovaries reveals heat shock proteins are associated with obesity related cancer risk. J Transl Med. 2024 Nov 26;22(1):1063. doi: 10.1186/s12967-024-05898-x.
18. Li Y, Liu H, Wu K, Liu H, Huang T, Chen ZJ, Zhao S*, Ma J*, Zhao H*. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis. J Pineal Res. 2019 Oct;67(3): e12601. doi:10.1111/jpi.12601.
19. Jiang YH, Man YY, Liu Y, Yin CJ, Li JL, Shi HC, Zhao H, Zhao S*. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice. Int J Mol Sci. 2021 Jan 7;22(2):550. doi: 10.3390/ijms22020550.
20. Li X, Tian Z, Cui R, Lv J, Yang X, Qin L, Liu Z, Zhang C, Jin C, Xu Y, Chen
ZJ, Zhao H, Zhao S. Association between Pregestational Vaginal Dysbiosis and Incident Hypertensive Disorders of Pregnancy Risk: a Nested Case-Control Study. mSphere. 2023 Jun 22;8(3):e0009623. doi: 10.1128/msphere.00096-23.
