姓名：赵世刚
邮箱：zsg0108@126.com
个人主页：https://faculty.sdu.edu.cn/zhaoshigang/
个人简介/Personal resume
副教授，医学博士，山东大学青年学者（未来计划）。师从于我国著名生殖医学专家陈子江院士，主要从事女性重大生殖内分泌代谢性疾病的病因学及临床分型防治研究，致力于探索生殖与代谢的交互作用关系。在国家重点研发计划子课题（2 项）、国家自然科学基金（面上项目和青年项目）、山东省重点研发计划及自然科学基金、中国博士后项目（面上和特别）等的资助下，以通讯作者（含共同） 发表SCI文章17篇。兼任Frontiers in Endocrinology期刊客座编辑、山东省医学会肥胖防治多学科联合委员会副主任委员、山东省研究型医院协会生殖医学研究分会委员等职务。
研究领域/Research direction
本课题组研究以肥胖和多囊卵巢综合征为代表的女性重大生殖内分泌代谢性疾病的病因学及临床分型诊疗。
主要研究课题：
1. 基于前沿组学技术的女性生殖代谢性疾病的可解释人工智能分型
2. 女性生殖内分泌代谢性疾病不同亚型对母婴健康的影响与机制研究
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学，妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
中华医学科技--青年科技奖
山东省医学会--青年科技奖
代表性论文/Representative publications
1.Zhang YQ, Han S, Liu CC, Zheng YW, Li H, Gao F, Bian YH, Liu X, Liu HB, Hu SR, Li YX, Chen ZJ *, Zhao S*, Zhao H*. THADA Inhibition Protects against Type 2 Diabetes Mellitus by Improving Pancreatic 2 β-cell Function and Preserving β-cell Mass. Nat Commun. 2023 Feb 23;14(1):1020. doi: 10.1038/s41467-023-36680-0.
2.Li Y, Liu H, Wu K, Liu H, Huang T, Chen ZJ, Zhao S*, Ma J*, Zhao H*. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis. J Pineal Res. 2019 Oct;67(3): e12601. doi:10.1111/jpi.12601.
3. Liu Z, Zheng Y, Wang B, Li J, Qin L, Li X, Liu X, Bian Y, Chen Z, Zhao H, Zhao S*. The impact of sleep on in vitro fertilization embryo transfer outcomes: a prospective study. Fertil Steril. 2023 Jan;119(1):47-55. doi:10.1016/j.fertnstert.2022.10.015.
4. Zhao S, Chen T, Yu M, Bian Y, Cao Y, Ning Y, Su S, Zhang J, Zhao S*. Novel WEE2 gene variants identified in patients with fertilization failure and female infertility. Fertil Steril. 2019 Mar;111(3):519-526. doi:10.1016/j.fertnstert.2018.11.018.
5. Jiang YH, Man YY, Liu Y, Yin CJ, Li JL, Shi HC, Zhao H, Zhao S*. Loss of miR-23b/27b/24-1 Cluster Impairs Glucose Tolerance via Glycolysis Pathway in Mice. Int J Mol Sci. 2021 Jan 7;22(2):550. doi: 10.3390/ijms22020550.
6. Jiang Y, Shi H, Liu Y, Zhao S*, Zhao H*. Applications of Melatonin in Female Reproduction in the Context of Oxidative Stress. Oxid Med Cell Longev. 2021 Jul 29;2021:6668365. doi: 10.1155/2021/6668365.
7. Tian Y, Li J, Su S, Cao Y, Wang Z, Zhao S*, Zhao H*. PCOS-GWAS Susceptibility Variants in THADA, INSR, TOX3, and DENND1A Are Associated With Metabolic Syndrome or Insulin Resistance in Women With PCOS. Front Endocrinol(Lausanne). 2020 Apr 30;11:274. doi: 10.3389/fendo.2020.00274.
8. Li Y, Liu H, Yu Q, Liu H, Huang T, Zhao S*, Ma J, Zhao H. Growth Hormone Promotes in vitro Maturation of Human Oocytes. Front Endocrinol (Lausanne). 2019 Jul 24;10:485. doi: 10.3389/fendo.2019.00485.
9. Li S, Qi J, Sun Y, Gao X, Ma J, Zhao S*. An integrated RNA-Seq and network study reveals that valproate inhibited progesterone production in human granulosa cells. J Steroid Biochem Mol Biol. 2021 Nov;214:105991. doi:10.1016/j.jsbmb.2021.105991.
10.Zhao R, Jiang Y, Zhao S*, Zhao H*. Multiomics Analysis Reveals Molecular Abnormalities in Granulosa Cells of Women With Polycystic Ovary Syndrome. Front Genet. 2021 May 18;12:648701. doi: 10.3389/fgene.2021.648701.
11. Jin C, Qin L, Liu Z, Li X, Gao X, Cao YZ, Zhao S*, Wang J, Han T, Yan L, Song J, Zhang F, Liu F, Zhang Y, Huang Y, Song Y, Liu Y, Yao Z, Chen H, Zhang Z, Zhao S, Feng Y, Zhang Y, Qian Y, Sun T, Feng Q, Zhao H*. Comparative Analysis of the Vaginal Microbiome Between Women with Polycystic Ovary Syndrome and Healthy Women: A Large-sample cross-sectional study. Reprod Biomed Online. 2023. Feb 09 doi: 10.1016/j.rbmo.2023.02.002
