姓名:秦莹莹
邮箱:qinyingying1006@163.com
个人主页:https://faculty.sdu.edu.cn/qinyingying/zh_CN/index.htm
个人简介/Personal resume
秦莹莹,山东大学二级教授、主任医师、博士生导师,现任生殖医学与子代健康全国重点实验室副主任,山东省立医院院长,山东省立医院党委副书记。
长期致力于女性生殖衰老的发生机理及临床诊疗研究。主持建立了国际最大规模的卵巢衰老疾病资源库、遗传数据库、前瞻队列平台,绘制了卵巢早衰(POI)遗传变异图谱,入选《中国2023年度重要医学进展》,阐明44个卵子发生发育基因缺陷导致卵巢衰老的新机制;解析卵巢早衰病因-表型谱,构建多维度卵巢衰老评估系统,研发生殖功能障碍基因筛查Panel,服务临床万余名女性;开展临床研究并研发靶向自调控及卵泡体外体内激活等延缓卵巢衰老的干预新策略,实现卵巢衰老的精准干预。
主持国家重点研发计划项目2项、基金委创新研究群体项目,国家青年科学基金项目(A类和B类)等多项国家级和省部级科研项目。入选2023年和 2024年入选妇产科学和内分泌与代谢两个领域的全球前2%顶尖科学家。参与撰写《生殖内分泌学》(副主编)、《步步精进-临床胚胎学与辅助生殖技术》(副主译)及《早发性卵巢功能不全临床诊疗中国专家共识》等专著及共识,为我国生殖障碍性疾病的规范化诊疗做出了重要贡献。先后荣获中国青年科技奖(2020)、全国妇幼健康科学技术奖自然科学一等奖(,2023)、全国巾帼建功标兵(2023)、中国青年女科学家奖(2022)、树兰医学青年奖(2021)和教育部高校科学研究优秀成果一等奖(2022)等。
研究领域/Research direction
本课题组研究---生殖内分泌疾病临床诊疗及发病机理研究
主要研究课题:生殖衰老的发病机制和临床诊疗研究
招生信息/Enrollment information
一级学科:临床医学
二级学科:妇产科学
学科方向:妇产科学/生殖医学
荣誉奖励/Honors & Awards
国家青年科学基金A类和B类
第十八届中国青年女科学家奖
第十六届中国青年科技奖
教育部青年学者
山东省青年专家
第八届树兰医学青年奖
第十一届山东省青年科技奖
山东省自然科学青年基金项目A类
山东医学科技奖科技创新成果奖一等奖
全国百篇优秀博士学位论文
代表性论文/Representative publications
1.Yan J#, Qin Y#, Zhao H#, Sun Y#, Gong F#, Li R#, Sun X#, Ling X#, Li H#, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro RS, Chen ZJ*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.
2.Qin Y#, Zhang F#, Chen ZJ*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019 Mar 14;380(11):1086.
3.Ke H#, Tang S#, Guo T#, Hou D, Jiao X, Li S, Luo W, Xu B, Zhao S, Li G, Zhang X, Xu S, Wang L, Wu Y, Wang J, Zhang F*, Qin Y*, Jin L*, Chen ZJ*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med. 2023 Feb 2.
4.Tang S#, Guo T#, Song C#, Wang L#, Zhang J, Rajkovic A, Lin X, Chen S, Liu Y, Tian W, Wu B, Wang S, Wang W, Lai Y, Wang A, Xu S, Jin L, Ke H, Zhao S, Li Y, Qin Y*, Zhang F*, Chen ZJ*. MGA loss-of-function variants cause premature ovarian insufficiency. J Clin Invest. 2024 Nov 15;134(22):e183758.
5.Wen C, Cao L, Wang S, Xu W, Yu Y, Zhao S, Yang F, Chen ZJ, Zhao S*, Yang Y*, Qin Y*. MCM8 interacts with DDX5 to promote R-loop resolution. EMBO J. 2024 Jul;43(14):3044-3071.
6.Yang Y#, Xu W#, Gao F#, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y*, Chen ZJ*, Zhao S*. Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2203208119.
7.Shao T#, Ke H#, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y*, Zhao S*. Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1. Autophagy. 2022 Aug;18(8):1864-1878.
8.Guo T#*, Liu H, Xu B, Qi Y, Xu K, Wu X, He X, Qin Y*, Chen ZJ*. Epidemiology, genetic etiology and intervention of premature ovarian insufficiency. Endocr Rev. 2025 Apr 3:bnaf011.
9.Wang X, Zhang X, Dang Y, Li D, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y*, Chen ZJ. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 May 7;48(8):4480-4491.
10.Wang Y#, Guo T#, Ke H, Zhang Q, Li S, Luo W, Qin Y*. Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency. Genet Med. 2021 Dec;23(12):2309-2315.
11.Cao Z, Wu X, Liu H, Xu K, Yang Y, Yang M, Wei D, Zhao S, Jiao X, Zhao Q, Zheng R*, Qin Y*, Guo T*, Chen ZJ*. Associations of long-term exposure to fine particulate matter and its components with ovarian aging: Evidence from a cross-sectional study in China. J Hazard Mater. 2025 May 12:494:138589.
12.Jiao X#, Zhang X#, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ*, Chen W*, Qin Y*. Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. Clin Transl Med. 2021 Jun;11(6):e448.
13.Zhang J, Yan L, Wang Y, Zhang S, Xu X, Dai Y, Zhao S, Li Z, Zhang Y, Xia G, Qin Y*, Zhang H*. In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human. Clin Transl Med. 2020 Sep;10(5):e182.
14.Zhou J#, Li C#, Mi X, Zho J, Chen C, Ren J, Liu R, Liu G, Chen ZJ, Qin Y*, Wu K*, Zhao S*. BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway. Cell Commun Signal. 2025 Mar 23;23(1):150.
15.Li C#, Dang Y#, Li J, Li H, Zhu Y, Qin Y*. Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities. Hum Reprod. 2021 Aug 18;36(9):2612-2621.