姓名：秦莹莹
邮箱：qinyingying1006@163.com
个人主页:
https://faculty.sdu.edu.cn/qinyingying/zh_CN/index.htm
个人简介/Personal resume
秦莹莹，山东大学二级教授、主任医师、博士生导师，现任生殖医学与子代健康全国重点实验室副主任，山东大学齐鲁医学院教学管理办公室主任、学科与发展规划办公室主任, 山东大学研究生院副院长（兼）、党委研究生工作部副部长（兼），山东大学附属生殖医院党委书记。
长期致力于提升女性生殖健康与防治出生缺陷的基础与临床转化研究：系统研究卵巢衰老发生机制，构建卵巢早衰突变全景图谱并揭示女性生殖衰老的遗传密码，入选《中国2023年度重要医学进展》；牵头建立国内最具规模的生殖衰老疾病资源库和队列平台，绘制我国女性全生命周期生殖储备特征；研发卵巢衰老基因筛查芯片及生育力挽救方法，成功应用于临床；开展高水平多中心临床研究，提供胚胎植入前非整倍体检测临床应用的循证医学I级证据。
主持国家重点研发计划2项、国家杰出青年基金、优秀青年基金等多项国家级和省部级科研项目。近5年以第一或通讯作者在NEJM、Nat Med、PNAS等期刊发表SCI论文70余篇。参与撰写《生殖内分泌学》（副主编）、《步步精进-临床胚胎学与辅助生殖技术》（副主译）及《早发性卵巢功能不全临床诊疗中国专家共识》等专著及共识。兼任中华医学会妇产科学分会委员、妇幼健康研究会生殖内分泌专委会常委、山东省医学会妇产科学分会副主任委员等。荣获全国妇幼健康科学技术奖自然科学一等奖、全国巾帼建功标兵、中国青年女科学家奖、中国青年科技奖、树兰医学青年奖等，入选妇产科学和内分泌与代谢领域2023年度全球前2%顶尖影响力科学家。
研究领域/Research direction
本课题组研究---生殖内分泌疾病临床诊疗及发病机理研究
主要研究课题：生殖衰老的发病机制和临床诊疗研究
招生信息/Enrollment information
一级学科：临床医学
二级学科：妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
国家杰出青年科学基金
国家优秀青年科学基金
第十八届中国青年女科学家奖
第十六届中国青年科技奖
教育部青年学者
第八届树兰医学青年奖
山东省青年专家
第十一届山东省青年科技奖
山东省自然科学杰出青年基金
山东医学科技奖科技创新成果奖一等奖
全国百篇优秀博士学位论文
代表性论文/Representative publications
1.Yan J#, Qin Y#, Zhao H#, Sun Y#, Gong F#, Li R#, Sun X#, Ling X#, Li H#, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro RS, Chen ZJ*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.
2.Qin Y#, Zhang F, Chen ZJ*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019 Mar 14;380(11):1086.
3.Ke H#, Tang S#, Guo T#, Hou D, Jiao X, Li S, Luo W, Xu B, Zhao S, Li G, Zhang X, Xu S, Wang L, Wu Y, Wang J, Zhang F*, Qin Y*, Jin L*, Chen ZJ*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med. 2023 Feb 2.
4.Wang X, Zhang X, Dang Y, Li D, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y*, Chen ZJ. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 May 7;48(8):4480-4491.
5.Shao T#, Ke H#, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y*, Zhao S*. Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1. Autophagy. 2022 Aug;18(8):1864-1878.
6.Yang Y#, Xu W#, Gao F#, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y*, Chen ZJ*, Zhao S*. Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2203208119.
7.Wang Y#, Guo T#, Ke H, Zhang Q, Li S, Luo W, Qin Y*. Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency. Genet Med. 2021 Dec;23(12):2309-2315.
8.Jiao X, Ke H, Qin Y*, Chen ZJ*. Molecular Genetics of Premature Ovarian Insufficiency. Trends Endocrinol Metab. 2018 Nov;29(11):795-807.
9.Jiao X#, Zhang X#, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ*, Chen W*, Qin Y*. Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. Clin Transl Med. 2021 Jun;11(6):e448.
10.Zhang J, Yan L, Wang Y, Zhang S, Xu X, Dai Y, Zhao S, Li Z, Zhang Y, Xia G, Qin Y*, Zhang H*. In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human. Clin Transl Med. 2020 Sep;10(5):e182.
11.Guo T#, Zheng Y#, Li G, Zhao S, Ma J, Qin Y*. Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency. Fertil Steril. 2020 Apr;113(4):845-852.
12.Li C#, Dang Y#, Li J, Li H, Zhu Y, Qin Y*. Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities. Hum Reprod. 2021 Aug 18;36(9):2612-2621.
13.Huang C, Guo T*, Qin Y*. Meiotic Recombination Defects and Premature Ovarian Insufficiency. Front Cell Dev Biol. 2021 Mar 8;9:652407.
14.Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y*. MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. J Cell Physiol. 2020 Nov;235(11):8826-8838.
15.Chen Q, Ke H, Luo X, Wang L, Wu Y, Tang S, Li J, Jin L, Zhang F*, Qin Y*, Chen X*. Rare deleterious BUB1B variants induce premature ovarian insufficiency and early menopause. Hum Mol Genet. 2020 Sep 29;29(16):2698-2707.
16.Ke H, Hu J, Zhao L, Ding L, Jiao X*, Qin Y*. Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection. Thyroid. 2020 Apr;30(4):588-597.
17.Luo W#, Guo T#, Li G, Liu R, Zhao S, Song M, Zhang L, Wang S, Chen ZJ, Qin Y*. Variants in Homologous Recombination Genes EXO1 and RAD51 Related with Premature Ovarian Insufficiency. J Clin Endocrinol Metab. 2020 Oct 1;105(10):dgaa505.
18.Zhang T#, Du X#, Zhao L#, He M, Lin L, Guo C, Zhang X, Han J, Yan H, Huang K, Sun G, Yan L, Zhou B, Xia G, Qin Y*, Wang C*. SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription. FASEB J. 2019 Dec;33(12):14703-14716.
19.Yang Y, Guo T, Liu R, Ke H, Xu W, Zhao S*, Qin Y*. FANCL gene mutations in premature ovarian insufficiency. Hum Mutat. 2020 May;41(5):1033-1041.
