姓名：秦莹莹
邮箱：qinyingying1006@163.com
个人主页:
https://faculty.sdu.edu.cn/qinyingying/zh_CN/index.htm
个人简介/Personal resume
秦莹莹，医学博士，教授，主任医师。主要从事生殖内分泌疾病临床诊疗及发病机理研究，取得系列原创性成果：系统研究卵巢衰老发生机制，发现多个早发性卵巢功能不全（POI）致病基因；牵头建立了国内最具规模的POI疾病资源库和前瞻性卵巢功能衰退队列；基于临床病理特征，筛选鉴定适用于中国 POI 病人、兼具敏感性与特异性的卵巢储备标志物和免疫预警指标；提出促进卵泡激活发育的干预新策略，开展腹腔镜下机械划痕激活卵泡，挽救POI患者生育力。主持国家重点研发计划2项、国家自然科学基金7项（包括国家杰出青年基金、优秀青年基金）、山东省重大基础研究项目1项等。近五年以第一或通讯作者在N Engl J Med、Nat Med、PNAS等期刊发表高水平论文70余篇，授权发明专利1项。参与制定《POI临床诊疗中国专家共识》，参与撰写《生殖内分泌学》（副主编）、《步步精进-临床胚胎学与辅助生殖技术》（副主译）、《The Ovary (3rd Edition)》（参编）等专著。多次受邀在国际及国内学术大会做专题报告。兼任中华医学会妇产分会委员、妇幼健康研究会生殖内分泌专委会常务委员、山东省医学会妇产科分会副主任委员等。
研究领域/Research direction
本课题组研究---生殖内分泌疾病临床诊疗及发病机理研究
主要研究课题：生殖衰老的发病机制和临床诊疗研究
招生信息/Enrollment information
一级学科：临床医学
二级学科：妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
国家杰出青年科学基金
国家优秀青年科学基金
第十八届中国青年女科学家奖
第十六届中国青年科技奖
教育部青年长江学者
第八届树兰医学青年奖
泰山学者青年专家
第十一届山东省青年科技奖
山东省自然科学杰出青年基金
山东医学科技奖科技创新成果奖一等奖
全国百篇优秀博士学位论文
代表性论文/Representative publications
1.Yan J#, Qin Y#, Zhao H#, Sun Y#, Gong F#, Li R#, Sun X#, Ling X#, Li H#, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro RS, Chen ZJ*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.
2.Qin Y#, Zhang F, Chen ZJ*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019 Mar 14;380(11):1086.
3.Ke H#, Tang S#, Guo T#, Hou D, Jiao X, Li S, Luo W, Xu B, Zhao S, Li G, Zhang X, Xu S, Wang L, Wu Y, Wang J, Zhang F*, Qin Y*, Jin L*, Chen ZJ*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nat Med. 2023 Feb 2.
4.Wang X, Zhang X, Dang Y, Li D, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y*, Chen ZJ. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 May 7;48(8):4480-4491.
5.Shao T#, Ke H#, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y*, Zhao S*. Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1. Autophagy. 2022 Aug;18(8):1864-1878.
6.Yang Y#, Xu W#, Gao F#, Wen C, Zhao S, Yu Y, Jiao W, Mi X, Qin Y*, Chen ZJ*, Zhao S*. Transcription-replication conflicts in primordial germ cells necessitate the Fanconi anemia pathway to safeguard genome stability. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2203208119.
7.Wang Y#, Guo T#, Ke H, Zhang Q, Li S, Luo W, Qin Y*. Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency. Genet Med. 2021 Dec;23(12):2309-2315.
8.Jiao X, Ke H, Qin Y*, Chen ZJ*. Molecular Genetics of Premature Ovarian Insufficiency. Trends Endocrinol Metab. 2018 Nov;29(11):795-807.
9.Jiao X#, Zhang X#, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ*, Chen W*, Qin Y*. Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. Clin Transl Med. 2021 Jun;11(6):e448.
10.Zhang J, Yan L, Wang Y, Zhang S, Xu X, Dai Y, Zhao S, Li Z, Zhang Y, Xia G, Qin Y*, Zhang H*. In vivo and in vitro activation of dormant primordial follicles by EGF treatment in mouse and human. Clin Transl Med. 2020 Sep;10(5):e182.
11.Guo T#, Zheng Y#, Li G, Zhao S, Ma J, Qin Y*. Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency. Fertil Steril. 2020 Apr;113(4):845-852.
12.Li C#, Dang Y#, Li J, Li H, Zhu Y, Qin Y*. Preimplantation genetic testing is not a preferred recommendation for patients with X chromosome abnormalities. Hum Reprod. 2021 Aug 18;36(9):2612-2621.
13.Huang C, Guo T*, Qin Y*. Meiotic Recombination Defects and Premature Ovarian Insufficiency. Front Cell Dev Biol. 2021 Mar 8;9:652407.
14.Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y*. MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. J Cell Physiol. 2020 Nov;235(11):8826-8838.
15.Chen Q, Ke H, Luo X, Wang L, Wu Y, Tang S, Li J, Jin L, Zhang F*, Qin Y*, Chen X*. Rare deleterious BUB1B variants induce premature ovarian insufficiency and early menopause. Hum Mol Genet. 2020 Sep 29;29(16):2698-2707.
16.Ke H, Hu J, Zhao L, Ding L, Jiao X*, Qin Y*. Impact of Thyroid Autoimmunity on Ovarian Reserve, Pregnancy Outcomes, and Offspring Health in Euthyroid Women Following In Vitro Fertilization/Intracytoplasmic Sperm Injection. Thyroid. 2020 Apr;30(4):588-597.
17.Luo W#, Guo T#, Li G, Liu R, Zhao S, Song M, Zhang L, Wang S, Chen ZJ, Qin Y*. Variants in Homologous Recombination Genes EXO1 and RAD51 Related with Premature Ovarian Insufficiency. J Clin Endocrinol Metab. 2020 Oct 1;105(10):dgaa505.
18.Zhang T#, Du X#, Zhao L#, He M, Lin L, Guo C, Zhang X, Han J, Yan H, Huang K, Sun G, Yan L, Zhou B, Xia G, Qin Y*, Wang C*. SIRT1 facilitates primordial follicle recruitment independent of deacetylase activity through directly modulating Akt1 and mTOR transcription. FASEB J. 2019 Dec;33(12):14703-14716.
19.Yang Y, Guo T, Liu R, Ke H, Xu W, Zhao S*, Qin Y*. FANCL gene mutations in premature ovarian insufficiency. Hum Mutat. 2020 May;41(5):1033-1041.
