姓名：李艳
邮箱：ubcliyan@sdu.edu.cn
个人主页：https://faculty.sdu.edu.cn/liyan30/zh_CN/index.htm
个人简介/Personal resume
李艳，医学博士，山东大学研究员，硕士生导师。加拿大不列颠哥伦比亚大学博士, 美国哈佛大学医学院/布莱根妇女医院博士后，山东大学未来计划青年学者。
长期致力于妇产科妊娠相关疾病子痫前期和复发性流产的发病机制研究及早期诊治方法的探索，关注人类滋养层细胞分化异常与妊娠相关疾病发生的病因分子机制，共发表SCI论文30篇，其中17篇以第一/通讯作者（含共同）发表于Trends Endocrinol Metab（封面文章）、Front Immunol、Hum Reprod、Clinical Science、J Clin Endocrinol Metab、FASEB Journal等杂志。
主持国家自然科学基金青年项目1项，作为学术骨干参与十四五“胎盘发育和功能的调节机制”国家重点研发计划1项，主持山东及江苏省级自然科学青年基金2项。担任国际期刊Biochemistry and Molecular Biology编委；美国ENDO年会摘要审稿专家；国际SCI期刊Frontiers in Oncology、Gynecologic Oncology、Journal of Cancer、Reproduction等审稿人; 美国内分泌学会ENDOCRINE SOCIETY和美国心脏协会AHA国际会员。
研究领域/Research direction
本课题组的研究面向“提高生殖健康水平、改善妇幼健康”的国家战略需求，致力于妊娠相关疾病如子痫前期和复发性流产的发病机制研究及早期诊治方法的探索。我们综合运用传统的细胞分子生物学，动物疾病模型，类器官培养体系，结合高通量测序，基因组学，生物信息学等手段，对妊娠早期母胎界面的发育和相互对话调控机制进行解析，致力于完善胎盘发育，子宫内膜蜕膜化，和胚胎早期发育的分子调控网络图谱，同时筛选疾病早期诊疗关键靶标分子，在丰富复发性流产和子痫前期病因机制的基础上，推动成果转化，助力此类临床常见妊娠相关疾病的早期预测、诊断和治疗。
主要研究课题：
1. 从胎盘发育角度探究子痫前期病因机制和早期诊疗策略
2. 早期妊娠丢失遗传和免疫机制的多维度研究
3. 利用滋养类器官和胚胎干细胞结合单细胞多组学在早期胚胎发育中功能的相关研究
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学/妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
1.山东医学科技一等奖（科技创新成果奖），2021年，山东医学科技奖奖励委员会。
2.山东大学青年学者未来计划，2020年，山东大学。
3. Y.W Loke新研究学者奖，2013年，胎盘发育国际协会（IFPA）。
代表性论文/Representative publications
1.Yan Li#, Junhao Yan#, Hsun-Ming Chang, Zi-Jiang Chen*, Peter C.K. Leung*. Roles of TGF-β superfamily proteins in extravillous trophoblast invasion. Trends in Endocrinology & Metabolism. 2021 Mar;32(3):170-189.
2.Xiangxin Lan#, Ling Guo#, Shiqin Zhu#, Yongzhi Cao, Yue Niu, Shuwen Han, Zeyan Li, Yan Li*, Junhao Yan*. First-Trimester Serum Cytokine Profile in Pregnancies Conceived After Assisted Reproductive Technology (ART) With Subsequent Pregnancy-Induced Hypertension. Front Immunol.2022Jul 1;13:930582. doi: 10.3389/fimmu.2022.930582.
3.Fengxuan Sun, Lei Cheng, Ling Guo, Shizhen Su, Yan Li*, Junhao Yan*. Activin A promotes human trophoblast invasion by upregulating integrin β3 via ALK4-SMAD4 signaling. Placenta. 2022 Nov;129:62-69.
4.Ling Guo#, Anliang Guo#, Fang Yang, Li Li, Junhao Yan, Xiaohui Deng, Caifeng Dai*, Yan Li*. Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure. Front Endocrinol (Lausanne). 2022 Jul 11;13:949123. doi: 10.3389/fendo.2022.949123.
5.Shiqin Zhu, Zeyan Li, Linlin Cui, Yanli Ban, Peter C.K. Leung, Yan Li*, Jinlong Ma*. Activin A increases human trophoblast invasion by up-regulating integrin β1 through ALK4. The FASEB Journal. 2021 Feb;35(2):e21220. doi: 10.1096/fj.202001604R .
6.Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan*, Yan Li*. Imaging-Based Body Fat Distribution in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Frontiers in Endocrinology. 2021 Sep 9;12:697223. doi: 10.3389/fendo.2021.697223.
7.Hong-Jin Zhao#*, Yan Li#, De-Yu Wang, Hai-Tao Yuan*. ARB might be superior to ACEI for treatment of hypertensive COVID-19 patients. J Cell Mol Med. 2021 Dec;25(23):11031-11034.
8.Yan Li*, Li Zhang, Francesca Polverino, Feng Guo, Yuan Hao, Taotao Lao, Shuang Xu, Lijia Li, Betty Pham, Caroline A. Owen, Xiaobo Zhou*. Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Scientific Reports. 2021 Apr 27;11(1):9074.
9.Hong-Jin Zhao, Christian Klausen, Hua Zhu, Hsun-Ming Chang, Yan Li*, Peter C.K. Leung*. Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated up-regulation of IGF binding protein-3. The FASEB Journal. 2020 Feb;34(2):3151-3164.
10.Hong-Jin Zhao, Hsun-Ming Chang, Christian Klausen, Hua Zhu, Yan Li*, Peter C.K. Leung*. Bone morphogenetic protein 2 induces the activation of WNT/β-catenin signaling and human trophoblast invasion through up-regulating BAMBI. Cellular Signalling. 2020 Mar;67:109489.
11.Hong-Jin Zhao, Xiao-Mei Yang, Ai-Hong Wang*, Yan Li*. Pharmacological Rationale for Antihypertensive Drug Choice on COVID-19 Affected Patients: ACEI/ARB might not increase their susceptibility. J Cell Mol Med. 2020 Sep 17; doi: 10.1111/jcmm.15850.
12.Yan Li, Michael H. Cho, Xiaobo Zhou*. What do polymorphisms tell us about the mechanisms of COPD? Clinical Science. 2017 Dec 4;131(24):2847-2863. doi: 10.1042/CS20160718.
13.Hongjin Zhao#, Yan Li#, Shanmei Liu, Xiangguo Sun, Min Li, Yan Hao, Lianqun Cui*, Aihong Wang*. Effect of calcium channels blockers and inhibitors of the renin-angiotensin system on renal outcomes and mortality in patients suffering from chronic kidney disease: systematic review and meta-analysis. Renal Failure. 2016 Jul;38(6):849-56. doi: 10.3109/0886022X.2016.1165065.
14.Yan Li, Christian Klausen, Hua Zhu, Peter C.K. Leung*. Activin A increases human trophoblast invasion by inducing SNAIL-mediated MMP2 up-regulation through ALK4. J Clin Endocrinol Metab. 2015 Nov;100(11):E1415-27. doi: 10.1210/jc.2015-2134.
15.Yan Li, Hua Zhu, Christian Klausen, Bo Peng, Peter C.K. Leung*. Vascular endothelial growth factor-A (VEGF-A) mediates activin A-induced human trophoblast endothelial-like tube formation. Endocrinology. 2015 Nov;156(11):4257-68. doi: 10.1210/en.2015-1228.
16.Yan Li, Christian Klausen, Jung-Chien Cheng, Hua Zhu, Peter C.K. Leung*. Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin. J Clin Endocrinol Metab. 2014 Nov;99(11):E2216-25. doi: 10.1210/jc.2014-2118.
17.Yan Li#, Hongjin Zhao#, Li Sun, Linjuan Huang, Qifeng Yang*, Beihua Kong* MDM2 SNP309 Is Associated with Endometrial Cancer Susceptibility: a meta-analysis. Human Cell. 2011Jun;24(2):57-64. doi: 10.1007/s13577-011-0013-4.
