姓名：李艳
邮箱：ubcliyan@sdu.edu.cn
个人主页：https://faculty.sdu.edu.cn/liyan30/zh_CN/index.htm
个人简介/Personal resume
李艳，医学博士，山东大学研究员，硕士生导师。加拿大不列颠哥伦比亚大学博士, 美国哈佛大学医学院/布莱根妇女医院博士后，山东大学未来计划青年学者。
围绕胎盘早期发育和功能异常，开展子痫前期、复发性流产等重大妊娠疾病的发生机理及临床诊疗研究，共发表SCI论文40篇，其中以第一/通讯作者（含共同）在EBioMedicine、Trends Endocrinol Metab（封面文章）、Cell Prolif、Front Immunol、Inflamm Res、Hum Reprod、Clinical Science、J Clin Endocrinol Metab、FASEB J等主流期刊发表SCI论文25篇。先后受邀在加拿大惠斯勒国际胎盘发育协会（IFPA）、美国华盛顿ATS年会、美国内分泌ENDO年会等国际学术会议做特邀报告，并荣获IFPA协会Y.W Loke New Investigator Award新研究学者奖。
主持国家自然科学基金青年项目1项，作为学术骨干参与十四五“胎盘发育和功能的调节机制”国家重点研发计划1项，主持山东及江苏省级自然科学青年基金2项。获得2021年山东省医学科技创新成果一等奖（2/7）。受邀担任国际期刊Front Cell Dev Biol、Biochemistry and Molecular Biology编委；2021-2023年美国ENDO年会摘要审稿专家；BMC Medicine、Front Immunol、Gynecol Oncol、Reproduction等20余个知名SCI期刊审稿人; 美国内分泌学会ENDOCRINE SOCIETY和美国心脏协会AHA国际会员。
研究领域/Research direction
本课题组面向“提高生殖健康水平、改善妇幼健康”的国家战略需求，致力于胎盘源性妊娠相关疾病（如子痫前期、复发性流产、反复胚胎种植失败）的发生机理及精准诊治策略研究。我们从内分泌、免疫、遗传以及表观遗传角度，综合运用细胞分子生物学，动物疾病模型，类器官培养体系，结合单细胞高通量测序，基因组学，生物信息学等手段，对妊娠早期母胎界面的发育和相互对话的调控机制进行阐释，致力于完善胎盘早期发育、子宫内膜蜕膜化、胚胎早期发育的分子调控网络图谱，同时鉴定疾病早期诊疗有效靶标分子，在丰富子痫前期和复发性流产病因机制的基础上，推动成果转化，助力此类临床常见妊娠相关疾病的早期精准预测、诊断和治疗。
主要研究课题：
1. 揭示胎盘源性妊娠疾病发生新机理
2. 阐明胎盘早期发育和功能调控新机制
3. 鉴定妊娠疾病高危因素及精准诊疗标志物
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学/妇产科学
学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
1.山东医学科技一等奖（科技创新成果奖），2021年，山东医学科技奖奖励委员会。
2.山东大学青年学者未来计划，2020年，山东大学。
3. Y.W Loke新研究学者奖，2013年，胎盘发育国际协会（IFPA）。
代表性论文/Representative publications
1.Jianye Deng#, Hong-Jin Zhao#, Ying Zhong#, Cuiping Hu, Jinlai Meng, Chunling Wang, Xiangxin Lan, Xiyao Wang, Zi-Jiang Chen, Junhao Yan*, Wei Wang*, Yan Li*. H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia. EBioMedicine. 2023 Jul;93:104664. doi: 10.1016/j.ebiom.2023.104664. (中科院一区Top)
2.Chunzi Lyu, Tianxiang Ni, Yaqiu Guo, Tingting Zhou, Zi-Jiang Chen, Junhao Yan*, Yan Li*. Insufficient GDF15 expression predisposes women to unexplained recurrent pregnancy loss by impairing extravillous trophoblast invasion. Cell Proliferation. 2023 Jun 4:e13514. doi: 10.1111/cpr.13514. (中科院一区Top)
3.Xiyao Wang#, Wenqiang Shi#, Shaotong Zhao, Deshun Gong, Shuo Li, Cuiping Hu, Zi-Jiang Chen, Yan Li*, Junhao Yan* (2023) Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage. Human Reproduction. 2023 May 2;38(5):1003-1018. doi: 10.1093/humrep/dead039. (中科院一区Top)
4.Yan Li#, Junhao Yan#, Hsun-Ming Chang, Zi-Jiang Chen*, Peter C.K. Leung*. Roles of TGF-β superfamily proteins in extravillous trophoblast invasion. Trends in Endocrinology & Metabolism. 2021 Mar;32(3):170-189. (封面文章, 中科院一区Top)
5.Ling Guo, Xiyao Wang, Yufeng Wang, Fengxuan Sun, Yifei Song, Caiyi Chen, Junhao Yan, Yan Li*. Impact of thyroid autoimmunity on pregnancy outcomes in euthyroid patients with recurrent implantation failure. Reprod Biomed Online. 2023 May 6:S1472-6483(23)00280-8. doi: 10.1016/j.rbmo.2023.05.001.
6.Xiangxin Lan#, Ling Guo#, Shiqin Zhu#, Yongzhi Cao, Yue Niu, Shuwen Han, Zeyan Li, Yan Li*, Junhao Yan*. First-Trimester Serum Cytokine Profile in Pregnancies Conceived After Assisted Reproductive Technology (ART) With Subsequent Pregnancy-Induced Hypertension. Front Immunol. 2022Jul 1;13:930582. doi: 10.3389/fimmu.2022.930582.
7.Ling Guo#, Xiangxin Lan#, Shanshan Liu#, Lianqiong Xu, Shiqin Zhu, Hong-Jin Zhao, Jinlai Meng*, Yan Li*. Distinct cytokine profiles in patients with preeclampsia. Inflammation Research. 2023 Apr;72(4):847-858. doi: 10.1007/s00011-023-01709-z.
8.Yan Li#, Yue Niu#, Mingxi Liu, Xiangxin Lan, Rencai Qin, Kongyang Ma, Hong-Jin Zhao. First-trimester serum antiphosphatidylserine antibodies serve as candidate biomarkers for predicting pregnancy-induced hypertension. Journal of Hypertension. 2023 Jun 27. doi: 10.1097/HJH.0000000000003498.
9.Zhaowen Zang, Min Hu, Yueyue Yan, Yaxin Su, Junhao Yan, Zi-Jiang Chen, Yan Li*. Pregnancy and neonatal outcomes in infertile patients with positive tuberculin skin test results. Reprod Biomed Online. 28 July 2023, 103307
10.Yue Niu, Lu Suo, Dingying Zhao, Yuhuan Wang, Ruolan Miao, Jialin Zou, Xinwei Han, Zi‑Jiang Chen, Yan Li*, Daimin Wei*. Is artifcial endometrial preparation more associated with early‑onset or late‑onset preeclampsia after frozen embryo transfer? J Assist Reprod Genet. 2023 Mar 31. doi: 10.1007/s10815-023-02785-0.
11.Fengxuan Sun, Lei Cheng, Ling Guo, Shizhen Su, Yan Li*, Junhao Yan*. Activin A promotes human trophoblast invasion by upregulating integrin β3 via ALK4-SMAD4 signaling. Placenta. 2022 Nov;129:62-69.
12.Ling Guo#, Anliang Guo#, Fang Yang, Li Li, Junhao Yan, Xiaohui Deng, Caifeng Dai*, Yan Li*. Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure. Front Endocrinol (Lausanne). 2022 Jul 11;13:949123. doi: 10.3389/fendo.2022.949123.
13.Shiqin Zhu, Zeyan Li, Linlin Cui, Yanli Ban, Peter C.K. Leung, Yan Li*, Jinlong Ma*. Activin A increases human trophoblast invasion by up-regulating integrin β1 through ALK4. The FASEB Journal. 2021 Feb;35(2):e21220. doi: 10.1096/fj.202001604R .
14.Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan*, Yan Li*. Imaging-Based Body Fat Distribution in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Frontiers in Endocrinology. 2021 Sep 9;12:697223. doi: 10.3389/fendo.2021.697223.
15.Hong-Jin Zhao#*, Yan Li#, De-Yu Wang, Hai-Tao Yuan*. ARB might be superior to ACEI for treatment of hypertensive COVID-19 patients. J Cell Mol Med. 2021 Dec;25(23):11031-11034.
16.Yan Li*, Li Zhang, Francesca Polverino, Feng Guo, Yuan Hao, Taotao Lao, Shuang Xu, Lijia Li, Betty Pham, Caroline A. Owen, Xiaobo Zhou*. Hedgehog interacting protein (HHIP) represses airway remodeling and metabolic reprogramming in COPD-derived airway smooth muscle cells. Scientific Reports. 2021 Apr 27;11(1):9074.
17.Hong-Jin Zhao, Christian Klausen, Hua Zhu, Hsun-Ming Chang, Yan Li*, Peter C.K. Leung*. Bone morphogenetic protein 2 promotes human trophoblast cell invasion and endothelial-like tube formation through ID1-mediated up-regulation of IGF binding protein-3. The FASEB Journal. 2020 Feb;34(2):3151-3164.
18.Hong-Jin Zhao, Hsun-Ming Chang, Christian Klausen, Hua Zhu, Yan Li*, Peter C.K. Leung*. Bone morphogenetic protein 2 induces the activation of WNT/β-catenin signaling and human trophoblast invasion through up-regulating BAMBI. Cellular Signalling. 2020 Mar;67:109489.
19.Hong-Jin Zhao, Xiao-Mei Yang, Ai-Hong Wang*, Yan Li*. Pharmacological Rationale for Antihypertensive Drug Choice on COVID-19 Affected Patients: ACEI/ARB might not increase their susceptibility. J Cell Mol Med. 2020 Sep 17; doi: 10.1111/jcmm.15850.
20.Yan Li, Michael H. Cho, Xiaobo Zhou*. What do polymorphisms tell us about the mechanisms of COPD? Clinical Science. 2017 Dec 4;131(24):2847-2863. doi: 10.1042/CS20160718.
21.Hongjin Zhao#, Yan Li#, Shanmei Liu, Xiangguo Sun, Min Li, Yan Hao, Lianqun Cui*, Aihong Wang*. Effect of calcium channels blockers and inhibitors of the renin-angiotensin system on renal outcomes and mortality in patients suffering from chronic kidney disease: systematic review and meta-analysis. Renal Failure. 2016 Jul;38(6):849-56. doi: 10.3109/0886022X.2016.1165065.
22.Yan Li, Christian Klausen, Hua Zhu, Peter C.K. Leung*. Activin A increases human trophoblast invasion by inducing SNAIL-mediated MMP2 up-regulation through ALK4. J Clin Endocrinol Metab. 2015 Nov;100(11):E1415-27. doi: 10.1210/jc.2015-2134.
23.Yan Li, Hua Zhu, Christian Klausen, Bo Peng, Peter C.K. Leung*. Vascular endothelial growth factor-A (VEGF-A) mediates activin A-induced human trophoblast endothelial-like tube formation. Endocrinology. 2015 Nov;156(11):4257-68. doi: 10.1210/en.2015-1228.
24.Yan Li, Christian Klausen, Jung-Chien Cheng, Hua Zhu, Peter C.K. Leung*. Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin. J Clin Endocrinol Metab. 2014 Nov;99(11):E2216-25. doi: 10.1210/jc.2014-2118.
25.Yan Li#, Hongjin Zhao#, Li Sun, Linjuan Huang, Qifeng Yang*, Beihua Kong*. MDM2 SNP309 Is Associated with Endometrial Cancer Susceptibility: a meta-analysis. Human Cell. 2011Jun;24(2):57-64. doi: 10.1007/s13577-011-0013-4.
