姓名：陈子江
邮箱：chenzijiang@vip.163.com
个人简介/Personal resume
陈子江，中国科学院院士，发展中国家科学院院士，山东大学讲席教授，博士生导师。国家百千万人才，“973”项目、国家重点研发计划首席科学家。曾任山东大学副校长、齐鲁医学院院长，现任山东大学妇儿医学研究中心主任、山东大学附属生殖医院首席专家、国家辅助生殖与优生工程技术研究中心主任、生殖内分泌教育部重点实验室主任、上海市辅助生殖与优生重点实验室主任、国际生殖学会联盟（IFFS）常务理事和WHO等国际组织特使。
从事妇产科学、生殖健康与出生缺陷临床诊疗和科学研究30余年，牵头系列多中心临床研究，解决了辅助生殖临床应用中的一些关键问题；主持制定了《多囊卵巢综合征诊断》标准和《不孕症诊断指南》等系列规范；阐释了不孕症等重大生殖障碍疾病的病因机制，揭示了人类配子、胚胎早期发育与调控关键规律。系列成果发表在N Engl J Med、Lancet、Science、Nature和Cell等。
研究领域/Research direction
主要研究课题：
1. 生殖内分泌疾病发病机制研究
2. 卵子发生和胚胎发育的调控研究
3. 生殖障碍疾病RCT与队列研究
4、出生缺陷防控研究
5.生殖医学新技术研发及转化应用
招生信息/Enrollment information
招生学科1
1.一级学科：临床医学
2.二级学科：妇产科学
3.学科方向：妇产科学/生殖医学
招生学科2
1.一级学科：基础医学
2.二级学科：基础科学
3.学科方向：细胞生物学
荣誉奖励/Honors & Awards
中国科学院院士
国家发明奖
国家科技进步奖
何梁何利科技进步奖
全国创新争先奖
谈家桢生命科学成就奖
代表性论文/Representative publications
1.Xuepeng Chen#, Yuwen Ke#, Keliang Wu#, Han Zhao#, Yaoyu Sun, Lei Gao, Zhenbo Liu, Jingye Zhang, Wenrong Tao, Zhenzhen Hou, Hui Liu, Jiang Liu* & Zi-Jiang Chen*. Key role for CTCF in establishing chromatin structure in human embryos. Nature. 2019 Dec;576(7786):306-310.
2.Zhuoning Zou, Chuanxin Zhang, Qiuyan Wang , Zhenzhen Hou , Zhuqing Xiong, Feng Kong, Qiujun Wang, Jinzhu Song, Boyang Liu , Bofeng Liu , Lijuan Wang , Fangnong Lai, Qiang Fan, Wenrong Tao, Shuai Zhao, Xiaonan Ma, Miao Li, Keliang Wu, Han Zhao*, Zi-Jiang Chen*, Wei Xie*. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science. 2022 Oct 7;378(6615):abo7923.
3.Lei Gao, Keliang Wu, Zhenbo Liu, Xuelong Yao, Shenli Yuan, Wenrong Tao, Lizhi Yi, Guanling Yu, Zhenzhen Hou, Dongdong Fan, Yong Tian, Han Zhao, Jianqiao Liu*, Zi-Jiang Chen*, Jiang Liu*. Chromatin Accessibility Landscape in Human Early Embryos and its Association with Evolution. Cell. 2018 Mar 22;173(1):248-259.e15.
4.Hanni Ke, Shuyan Tang, Ting Guo, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu, Jiucun Wang, Feng Zhang*, Yingying Qin*, Li Jin*, Zi-Jiang Chen*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023, In press. 2023 Feb 2.doi: 10.1038/s41591-022-02194-3. Online ahead of print.
5.Junhao Yan#, Yingying Qin#, Han Zhao#, Yun Sun#, Fei Gong#, Rong Li#, Xiaoxi Sun#, Xiufeng Ling#, Hong Li#, … , Heping Zhang, Richard S Legro, Zi-Jiang Chen*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058.
6.Yuhua Shi, Yun Sun, Cuifang Hao, Heping Zhang, Daimin Wei, Yunshan Zhang, Yimin Zhu, Xiaohui Deng, Xiujuan Qi, Hong Li, Xiang Ma, Haiqin Ren, Yaqin Wang, Dan Zhang, Bo Wang, Fenghua Liu, Qiongfang Wu, Ze Wang, Haiyan Bai, Yuan Li, Yi Zhou, Mei Sun, Hong Liu, Jing Li, Lin Zhang, Xiaoli Chen, Songying Zhang, Xiaoxi Sun, Richard S. Legro, and Zi-Jiang Chen*. Frozen versus Fresh Embryo Transfer in Ovulatory Women. N Engl J Med, 2018 Jan 11; 378:126-36.
7.Yingying Qin, Feng Zhang, Zi-Jiang Chen*. BRCA2 in Ovarian Development and Function. N Engl J Med. 2019; 380:1086-1087.
8.Zi-Jiang Chen*, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng, Lifeng Tian, Cuifang Hao, Dongzi Yang, Feng Zhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao, Heping Zhang, Richard S. Legro. Fresh versus Frozen Embryos for Infertility in Polycystic Ovary Syndrome. N Engl J Med, 2016 Aug 11; 375(6):523-33.
9.Daimin Wei, Jia-Yin Liu, Yun Sun, Yuhua Shi, Bo Zhang, Jian-Qiao Liu, Jichun Tan, Xiaoyan Liang, Yunxia Cao, Ze Wang, Yingying Qin, Han Zhao, Yi Zhou, Haiqin Ren, Guimin Hao, Xiufeng Ling, Junzhao Zhao, Yunshan Zhang, Xiujuan Qi, Lin Zhang, Xiaohui Deng, Xiaoli Chen,Yimin Zhu, Xiaohong Wang, Li-Feng Tian, Qun Lv, Xiang Ma, Heping Zhang, Richard S Legro, Zi-Jiang Chen*. Frozen versus fresh single blastocyst transfer in ovulatory women: a multicenter, randomized controlled trial. Lancet. 2019 Mar 30;393(10178):1310-1318.
10.Yongyong Shi, Han Zhao, Yuhua Shi, Yunxia Cao, Dongzi Yang, Zhiqiang Li,Bo Zhang, Xiaoyan Liang, Tao L, Jianhua Chen, Jiawei Shen, Junzhao Zhao,Li You, Xuan Gao, Dongyi Zhu, Xiaoming Zhao, Ying Yan, Yingying Qin, Wenjin Li, Junhao Yan, Qingzhong Wang, Junli Zhao, Ling Geng, Jinlong Ma, Yueran Zhao,Guang He, Aiping Zhang, Shuhua Zou, Aijun Yang, Jiayin Liu, Weidong Li, Baojie Li, Chunling Wan, Ying Qin, Juanzi Shi, Jing Yang, Hong Jiang, Jin-e Xu, Xiujuan Qi, Yun Sun,Yajie Zhang, Cuifang Hao, Xiuqing Ju, Dongni Zhao, Chun-e Ren, Xiuqing Li, Wei Zhang, Yiwen Zhang, Jiangtao Zhang, Di Wu, Changming Zhang, Lin He*, and Zi-Jiang Chen*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012; 44(9): 1020-5.
11.Keliang Wu, Cuiqing Zhong, Tailai Chen, Xiaoyu Zhang, Wenrong Tao, Jingye Zhang, Hongchang Li, Han Zhao*, Jinsong Li* and Zi-Jiang Chen*..Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy. Cell Research. 2017 Aug; 27(8):1069-1072.
12.Tailai Chen, Yuehong Bian, Xiaoman Liu, Shigang Zhao, Keliang Wu, Lei Yan, Mei Li, Zhenglin Yang, Hongbin Liu, Han Zhao*, Zi-Jiang Chen*. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. Am J Hum Genet. 2017 Sep 7; 101(3):459-465.
