姓名：马金龙
邮箱：majinlong123@hotmail.com
个人简介/Personal resume
山东大学教授、博导，国家重点研发计划首席专家。现任国家辅助生殖与优生工程技术研究中心副主任、山东省生殖健康技术创新中心常务副主任、香港中文大学-山东大学生殖遗传联合实验室中方主任，兼任山东省医学会生殖医学分会主任委员等。从事胚胎发育和优生学研究与临床教学工作30余年，重点开展辅助生殖出生队列研究、胚胎与配子发生机制和出生缺陷的发生机理与临床转化研究。先后主持国家重点研发计划、国家自然科学基金等课题20余项，在国内外杂志上发表论文100余篇，其中SCI收录60余篇，主编、参编教材10余部，获国家和省部级科技奖励8项，获得国际、国内发明专利30余件。培养研究生60余人，获教育部先进个人等荣誉称号。
主要学术创新：1.首次回顾性队列研究分析了中国辅助生殖周期中获卵数量与活产率之间的相关性，为临床上采取更优的治疗方案提供了高质量证据；2.课题组合作研究首次发现褪黑素能够促进人类卵母细胞成熟及早期胚胎发育；3.首次发现CFAP61基因缺失可以导致小鼠精子鞭毛发育异常，从而引起精子质量下降进而导致雄性不育，为临床上深入理解男性不育病因机制提供了新思路；
研究领域/Research direction
辅助生殖子代健康、胚胎发育和配子发生、出生缺陷防治技术研究与临床转化、产品研发等。
主要研究课题：
1. 辅助生殖医疗产品的自主研发与生产，国家重点研发计划（首席专家）；
2. miR-370-3p/miR-411-5p在原发性卵巢功能不全发病中的作用及机制研究，国家自然科学基金面上项目（项目负责人）
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学/妇产科学
学科方向：生殖医学
荣誉奖励/Honors & Awards
荣获教育部先进个人和山东大学优秀教师等荣誉
代表性论文/Representative publications
1.Yue Li, Hui Liu, Keliang Wu, Hongbin Liu, Tao Huang, Zi-Jiang Chen, Shigang Zhao*, Jinlong Ma*, Han Zhao*. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis. J Pineal Res. 2019 Oct;67(3):e12601.
2.Tao Huang, Yingying Yin, Chao Liu, Mengjing Li, Xiaochen Yu, Xiuge Wang, Haobo Zhang, Tahir Muhammad, Fei Gao, Wei Li, Zi-Jiang Chen*, Hongbin Liu*, Jinlong Ma*. Absence of murine CFAP61 causes male infertility due to multiple morphological abnormalities of the flagella. Sci Bull. 2020 May 30;65(10):854-864.
3.Jingyu Li, Linlin Cui, Xiao Jiang, Han Zhao, Shigang Zhao, Yuhua Shi, Daimin Wei, Li You, Jinlong Ma*, Zi-Jiang Chen*. Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring. Hum Reprod. 2020 Jul 1;35(7):1711-1718. doi: 10.1093/humrep/deaa125.
4.Jingmei Hu, Shidou Zhao, Chengyan Xu, Lin Zhang, Shaoming Lu, Linlin Cui, Jinlong Ma*, Zi-Jiang Chen. Liquid nitrogen vapor is comparable to liquid nitrogen for storage of cryopreserved human sperm: evidence from the characteristics of post-thaw human sperm. Fertil Steril. 2015 Nov; 104(5):1253-1257.e2.
5.Zhen Xu, Lei Yan, Wen Liu, Xinxin Xu, Miao Li, Lingling Ding, Jinlong Ma*, Zi-Jiang Chen. Effect of treatment of a previous ectopic pregnancy on in vitro fertilization–intracytoplasmic sperm injection outcomes: a retrospective cohort study. Fertil Steril. 2015 Dec; 104(6):1446-1451.e3.
6.Huidan Wang, Mei Sun, Yingying Qin, Tingting Xia, Jinlong Ma*, Zi-Jiang Chen. Mutations in DMC1 are not responsible for premature ovarian failure in Chinese women. Reprod Biomed Online. 2013; 26(2): 175-8.
7.Yang Li, Hongbin Liu, Han Zhao, Chengyan Xu, Yueran Zhao, Jinlong Ma*, Zi-Jiang Chen. Association of AQP8 in women with PCOS. Reprod Biomed Online. 2013 Oct; 27(4):419-22.
8.Jingjuan Ji, Yusheng Liu, Xian Hong Tong, Lihua Luo, Jinlong Ma*, and Zijiang Chen. The optimum number of oocytes in IVF treatment: an analysis of 2455 cycles in China. Hum Reprod. 2013 Oct; 28(10):2728-34.
9.Zi-Jiang Chen*, Han Zhao, Lin He, Yuhua Shi, Yingying Qin, Yongyong Shi*, Zhiqiang Li, Li You, Junli Zhao, Jiayin Liu, Xiaoyan Liang, Xiaoming Zhao, Junzhao Zhao, Yingpu Sun, Bo Zhang, Hong Jiang, Dongni Zhao, Yuehong Bian, Xuan Gao, Ling Geng, Yiran Li, Dongyi Zhu, Xiuqin Sun, Jin-e Xu, Cuifang Hao, Chun-e Ren, Yajie Zhang, Shiling Chen, Wei Zhang, Aijun Yang, Junhao Yan, Yuan Li, Jinlong Ma, Yueran Zhao. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics. 2011; 43(1): 55–59.
10.Jing Li, Qian Sun, Meng Zhang, Xiao Fu, Yiting Zhang, Shanshan Gao* & Jinlong Ma*. Natural cycles achieve better pregnancy outcomes than artificial cycles in non-PCOS women undergoing vitrified single-blastocyst transfer: a retrospective cohort study of 6840 cycles. Reprod Biol Endocrinol. 2021 Apr 9;19(1):55.
