姓名：高媛
邮箱：gaoyuan@sduivf.com
个人简介/Personal resume
高媛，免疫学博士，研究员。现任国家辅助生殖与优生工程技术研究中心、山东大学生殖医学研究中心分子遗传室主任。国家重点研发计划首席科学家，作为项目负责人、课题负责人及PI主持参与国家重点研发计划4项、主持省重点研发计划、自然基金面上项目等6项；参与多项国家973、863计划及国家重大专项科研计划的研究，以通讯或第一作者发表研究论文30余篇，获国际及国内发明专利授权3项，成果转让3项。目前主要从事分子遗传技术在生殖遗传学中的临床应用及研发工作。在单基因遗传病的基因检测与诊断及胚胎植入前遗传学检测（PGT）方面积累了丰富的经验。
研究领域/Research direction
本课题组研究---
主要研究课题：1. 遗传性疾病的分子遗传学检测、诊断与相关机理研究
2. 胚胎植入前遗传学检测与诊断
3. 遗传咨询
招生信息/Enrollment information
招生学科（一级和二级学科）：基础医学/基础科学
学科方向：细胞生物学/生物学
荣誉奖励/Honors & Awards
济南市创新团队领军人才、经纬人才
代表性论文/Representative publications
作者 论文标题 期刊名 出版年 卷期页码
1. Zou Y, Xie H, Hu J, Cui L, Liu G, Wang L, Xue M, Yan J, Gao X, Gao Y*, Chen ZJ. The low fetal fraction at the first trimester is associated with adverse pregnancy outcomes in IVF singleton pregnancies with single embryo transfer from frozen cycles. J Assist Reprod Genet. 2022 Jul;39(7):1603-1610（通讯作者IF 3.412）
2. Se-Xin Huang, Yuping Niu, Jie Li, Ming Gao, Yan Zhang, Junhao Yan, Shuiying Ma, Xuan Gao,Yuan Gao*, Complex preimplantation genetic tests for Robertsonian translocation, HLA and X-Linked Hyper IgM Syndrome caused by a novel mutation of CD40LG gene, J Assist Reprod Genet.2020, （通讯作者IF 3.412）
3. Ming Gao, Lijuan Wang, Peixen Xu, Hongqiang Xie, Xiaowei liu, Sexin Huang, Yang Zou, Jie Li, Yang Wang, Pidong Li,Yuan Gao*,Zi-Jiang Chen, Noncarrier embryo selection and transfer in preimplantation genetic testing cycles for reciprocal translocation by Oxford Nanopore Technologies，Journal of Genetics and Genomics, 2020, （通讯作者IF 4.275）
4. Peiwen Xu, Ruirui Li, Sexin Huang, Menghan Sun, Jiaolong Liu, Yuping Niu, Yang Zou, Jie Li, Ming Gao, Xiaolei Li, Xuan Gao,Yuan Gao*, A Novel Splicing Mutation in the FBN2 Gene in a Family With Congenital Contractural Arachnodactyly, Frontiers in Genentics, 2020;11:143. (通讯作者IF 4.599)
5. Wu Keliang, Chen Tailai,Sexin Huang, Cuiqing Zhong, Junhao Yan, Xiaoyu Zhang, Jinsong Li, Gao Yuan*, Zhao Han*，Chen Zijiang*. Mitochondrial replacement by pre-pronuclear transfer in human embryos. Cell Research. 2017 Jun;27(6):834-837.（共同通讯作者，IF:25.612)
6. Xiong WP, Wang DY, Gao Y#, Gao Ya, Wang HongYang, Guan Jing, Lan Lan, Yan Junhao, Zong Liang, Yuan Yuan, Dong Wei, Huang Sexin, Wu Keliang, Wang Yaoshen, Wang Zhili, Peng HongMei, Lu Yanping, Xie Linyi, Zhao Cui, Wang Li, Zhang QiuJing, Gao Yun, Li Na, Yang Ju, Yin ZiFang, Han Bing, Wang Wei, Chen Zi-Jiang, Wang QiuJu, Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment. Science China Life Sciences, 2015;58:829-838. (共同第一作者) (SCI:6.038)
