姓名：高媛
邮箱：gaoyuan@sduivf.com
个人简介/Personal resume
高媛，免疫学博士，研究员，博士生导师。山东大学国家辅助生殖与优生工程技术研究中心和山东省生殖健康技术创新中心副主任，山东大学附属生殖医院分子遗传室主任，济南市创新团队领军人才、经纬人才。国家重点研发计划首席科学家，作为项目负责人、课题负责人及PI主持参与国家重点研发计划5项，主持国自然、省自然、省重点研发计划等10余项，横向课题10余项。以通讯作者发表论文30余篇，包括Cell Research（2篇）、eBioMedicine、JGG、NPJ Genom Med、Prenatal Diagnosis（封面文章）等，牵头制定医药行业标准1项，牵头制定专家共识1项，获得国际及国内发明专利授权10项，实现成果转化3项。目前，主要从事分子遗传技术在生殖遗传学中的临床应用及研发工作，在单基因遗传病的基因检测与诊断及胚胎植入前遗传学检测（PGT）方面积累了丰富的经验。
研究领域/Research direction
本课题组主要研究课题：
1. 遗传病的作用机制研究及分子检测产品研发；
2. 胚胎植入前遗传学检测与诊断；
3. 遗传咨询；
招生信息/Enrollment information
招生学科（一级和二级学科）：基础医学/基础科学
学科方向：细胞生物学/生物学
荣誉奖励/Honors & Awards
济南市创新团队领军人才、经纬人才
代表性论文/Representative publications
1. Gao Y, Yi L, Zhan J, Wang L, Yao X, Yan J, Jian S, Gao L, Farangez M, Gao M, Zou Y, Gao X, Wu K, Liu J, Chen ZJ. A clinical study of preimplantation DNA methylation screening in assisted reproductive technology. Cell Res. 2023 Jun;33(6):483-485. （第一&通讯作者，中科院1区）
2. Zhang S, Gao Y, Wang X, Li Q, Tan J, Liang B, Gao M, Wu J, Ling X, Liu J, Teng X, Li H, Sun Y, Huang W, Tong X, Lei C, Li H, Wang J, Li S, Xu X, Zhang J, Wu W, Liang S, Ou J, Zhao Q, Jin R, Zhang Y, Xu C, Lu D, Yan J, Sun X, Choy KW, Xu C, Chen ZJ. Preimplantation genetic testing for structural rearrangements by genome-wide SNP genotyping and haplotype analysis: a prospective multicenter clinical study. EBioMedicine. 2025 Jan;111:105514.（第一作者，中科院1区）
3. Sun Q, Xu P, Mao A, Huang S, Li J, Chen L, Li J, Kan H, Huang J, Ji W, Si D, Yan J, Chen ZJ, Gao X, Gao Y. Targeted long-read sequencing enables higher diagnostic yield of ADPKD by accurate PKD1 genetic analysis. NPJ Genom Med. 2025 Mar 11;10(1):22.（通讯作者，中科院2区）
4. Wang J, Xie H, Zou Y, Gao M, Wang L, Liu X, Huang SX, Yan J, Gao Y. The use of blastocysts developing from nonpronuclear and monopronuclear zygotes can be considered in PGT-SR: a retrospective cohort study. BMC Pregnancy Childbirth. 2025 May 3;25(1):530. （通讯作者，中科院2区）
5. Zou Y, Cui L, Xue M, Yan J, Huang M, Gao M, Gao X, Gao Y, Chen ZJ. Applications of noninvasive prenatal testing in vanishing twin syndrome pregnancies after treatment of assisted reproductive technology in a single center. Prenat Diagn. 2021 Jan;41(2):226-233. (通讯作者，中科院2区，封面文章)
6. Ming Gao, Lijuan Wang, Peixen Xu, Hongqiang Xie, Xiaowei liu, Sexin Huang, Yang Zou, Jie Li, Yang Wang, Pidong Li,Yuan Gao*,Zi-Jiang Chen, Noncarrier embryo selection and transfer in preimplantation genetic testing cycles for reciprocal translocation by Oxford Nanopore Technologies，Journal of Genetics and Genomics, 2020, （通讯作者，中科院1区）
7. Wu Keliang, Chen Tailai,Sexin Huang, Cuiqing Zhong, Junhao Yan, Xiaoyu Zhang, Jinsong Li, Gao Yuan*, Zhao Han*，Chen Zijiang*. Mitochondrial replacement by pre-pronuclear transfer in human embryos. Cell Research. 2017 Jun;27(6):834-837.（通讯作者，中科院1区)
8. Xiong WP, Wang DY, Gao Y#, Gao Ya, Wang HongYang, Guan Jing, Lan Lan, Yan Junhao, Zong Liang, Yuan Yuan, Dong Wei, Huang Sexin, Wu Keliang, Wang Yaoshen, Wang Zhili, Peng HongMei, Lu Yanping, Xie Linyi, Zhao Cui, Wang Li, Zhang QiuJing, Gao Yun, Li Na, Yang Ju, Yin ZiFang, Han Bing, Wang Wei, Chen Zi-Jiang, Wang QiuJu, Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment. Science China Life Sciences, 2015;58:829-838. (第一作者，中科院1区)
