姓名：赵涵

邮箱：hanzh80@sdu.edu.cn

个人简介/Personal resume

赵涵，山东大学教授，主任医师，博士生导师，现任生殖内分泌教育部重点实验室副主任，山东大学附属生殖医院副院长。 获CJ特聘教授、国自然YQ、“新世纪优秀人才”、山东省级特聘专家、领军人才。兼任中国医疗保健国家交流促进会生殖医学分会副秘书长、中国医师协会生殖医学专业青年委员会-副主任委员、山东省医师协会青春期医学专业委员会副主任委员等多项职务。近年以通讯或第一作者（含共同）在NEJM、Nature、Science、Nat Genet、Cell Res、AJHG、PNAS 等杂志发表SCI论文 50余篇。主持国家重点研发计划（首席）、国自然重大项目子课题等十余项目。获中华医学会青年科技奖、霍英东教育基金青年科学奖和吴孟超医学青年奖等。

研究领域/Research direction

本课题组研究方向为生殖障碍疾病的发病机制和辅助生殖技术研究

主要研究课题：

生殖障碍疾病发病机制和精准诊疗

人类早期胚胎发育规律

辅助生殖技术优化及产品研发

招生信息/Enrollment information

招生学科（一级和二级学科）：临床医学/妇产科学

学科方向：生殖医学

荣誉奖励/Honors & Awards

l “CJ学者奖励计划"特聘教授

l霍英东教育基金会高等院校青年科学奖

l中华医学科技奖青年奖

l吴孟超医学青年基金奖

l山东大学 “优秀临床教师”

l山东省科学技术奖“自然科学一等奖”（第二位）

l山东省级特聘专家

l山东省级领军人才

l山东省自然科学基金“杰出青年基金”获得者

l国家自然科学基金“YQ”获得者

l中国生理学会生殖科学专业委员会第一届青年科技奖

l教育部“新世纪优秀人才支持计划”

代表性论文/Representative publications

1.Zou Z#, Zhang C#, Wang Q#, Hou Z#, Xiong Z, Kong F, Wang Q, Song J, Liu B, Liu B, Wang L, Lai F, Fan Q, Tao W, Zhao S, Ma X, Li M, Wu K, Zhao H*, Chen ZJ*, Xie W*. Translatome and transcriptome co-profiling reveals a role of TPRXs in human zygotic genome activation. Science. 2022 Sep 8:eabo7923.

2.Yan J#, Qin Y#, Zhao H#, Sun Y, Gong F, Li R, Sun X, Ling X, Li H, Hao C, Tan J, Yang J, Zhu Y, Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K, Gao Y, Shi Y, Lu Y, Zhang T, Wu W, Ma X, Ma H, Fu J, Zhang J, Meng Q, Zhang H, Legro RS, Chen ZJ*. Live Birth with or without Preimplantation Genetic Testing for Aneuploidy. N Engl J Med. 2021 Nov 25;385(22):2047-2058

3.Chen X#, Ke Y#, Wu K#, Zhao H#, Sun Y, Gao L, Liu Z, Zhang J, Tao W, Hou Z, Liu H, Liu J*, Chen ZJ*. Key role for CTCF in establishing chromatin structure in human embryos. Nature. 2019 Dec;576(7786):306-310.

4.Chen ZJ*, Zhao H#, He L#, Shi Y#, Qin Y, Shi Y*, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet. 2011 Jan;43(1):55-9

5.Shi Y#, Zhao H#, Shi Y#, Cao Y#, Yang D#, Li Z#, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L*, Chen ZJ*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet. 2012 Sep;44(9):1020-5

6.Zhang H#, Chen T#, Wu K#, Hou Z#, Zhao S, Zhang C, Gao Y, Gao M, Chen ZJ*, Zhao H*. Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor. Cell Res. 2021 Jul;31(7):814-817

7.Wu K#, Chen T#, Huang S, Zhong C, Yan J, Zhang X, Li J, Gao Y*, Zhao H*, Chen ZJ*. Mitochondrial replacement by pre-pronuclear transfer in human embryos. Cell Res. 2017 Jun;27(6):834-837

8.Wu K#, Zhong C#, Chen T#, Zhang X, Tao W, Zhang J, Li H, Zhao H*, Li J*, Chen ZJ*. Polar bodies are efficient donors for reconstruction of human embryos for potential mitochondrial replacement therapy. Cell Res. 2017 Aug;27(8):1069-1072

9.Zhang XM#, Wu K#, Zheng Y#, Zhao H#, Gao J, Hou Z, Zhang M, Liao J, Zhang J, Gao Y, Li Y, Li L, Tang F*, Chen ZJ*, Li J*. In vitro expansion of human sperm through nuclear transfer. Cell Res. 2020 Apr;30(4):356-359

10.Yuan S#, Zhan J#, Zhang J#, Liu Z, Hou Z, Zhang C, Yi L, Gao L*, Zhao H*, Chen ZJ*, Liu J*, Wu K*. Human zygotic genome activation is initiated from paternal genome.Cell Discov. 2023 Jan 31;9(1):13

11.Liu Y#, Zhao H#, Shao F#, Zhang Y#, Nie H, Zhang J, Li C, Hou Z, Chen ZJ, Wang J*, Zhou B*, Wu K*, Lu F*. Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition. Nat Struct Mol Biol. 2023 Jan 16. doi: 10.1038/s41594-022-00908-2. Epub ahead of print.

12.Li Y#, Liu H#, Wu K, Liu H, Huang T, Chen ZJ, Zhao S*, Ma J*, Zhao H*. Melatonin promotes human oocyte maturation and early embryo development by enhancing clathrin-mediated endocytosis. J Pineal Res. 2019 Oct;67(3):e12601.

13.Chen T#, Bian Y#, Liu X, Zhao S, Wu K, Yan L, Li M, Yang Z, Liu H, Zhao H*, Chen ZJ*. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. Am J Hum Genet. 2017 Sep 7;101(3):459-465.

14.Zhao H#, Xu J#, Zhang H#, Sun J#, Sun Y#, Wang Z, Liu J, Ding Q, Lu S, Shi R, You L, Qin Y, Zhao X, Lin X, Li X, Feng J, Wang L, Trent JM, Xu C, Gao Y, Zhang B, Gao X, Hu J, Chen H, Li G, Zhao J, Zou S, Jiang H, Hao C, Zhao Y, Ma J, Zheng SL, Chen ZJ*. A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. Am J Hum Genet. 2012 May 4;90(5):900-6.

15.Zhao H#, Chen ZJ#, Qin Y, Shi Y, Wang S, Choi Y, Simpson JL, Rajkovic A*. Transcription factor FIGLA is mutated in patients with premature ovarian failure. Am J Hum Genet. 2008 Jun;82(6):1342-8.