姓名：赵涵
邮箱：hanzh80@sdu.edu.cn
个人简介/Personal resume
赵涵，山东大学二级教授，主任医师，博士生导师，为CJ特聘教授、国自然YQ、“新世纪优秀人才”、山东省卫生健康领军人才。现任山东大学妇儿与生殖健康研究院执行院长，生殖医学与子代健康全国重点实验室副主任，生殖内分泌教育部重点实验室副主任。近年以通讯或第一作者（含共同）在NEJM、BMJ、Nature、Science、Cell Stem Cell、Nat Med、Nat Genet、Cell Res、STTT、Cell Metab、Nat Commun等杂志发表SCI论文90余篇。主持国家重点研发计划（首席）、国自然重大项目子课题等二十余项目。获国家科技进步二等奖、教育部高等学校科学研究优秀成果一等奖、中国青年女科学家奖团队奖、中华医学科技奖青年奖、树兰医学青年奖等奖励。
研究领域/Research direction
本课题组研究方向为生殖障碍疾病的发病机制和辅助生殖技术研究
主要研究课题：
生殖障碍疾病发病机制和精准诊疗
人类早期胚胎发育规律
辅助生殖技术优化及产品研发
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学/妇产科学
学科方向：生殖医学
荣誉奖励/Honors & Awards
• “CJ学者奖励计划"特聘教授
• 中国青年女科学家奖团队奖
• 树兰医学青年奖
• 霍英东教育基金会高等院校青年科学奖
• 中华医学科技奖青年奖
• 吴孟超医学青年基金奖
• 山东大学 “优秀临床教师”
• 山东省科学技术奖“自然科学一等奖”（第二位）
• 山东省级特聘专家
• 山东省级领军人才
• 山东省自然科学基金“杰出青年基金”获得者
• 国家自然科学基金“YQ”获得者
• 中国生理学会生殖科学专业委员会第一届青年科技奖
• 教育部“新世纪优秀人才支持计划”
代表性论文/Representative publications
1.Zou Z#, Zhang C#, Wang Q#, Hou Z#, XiongZ,KongF, WangQ,Song J,LiuB,LiuB,WangL,Lai F, Fan Q, Tao W, ZhaoS, Ma X, Li M, Wu K,ZhaoH*,ChenZJ*,Xie W*.Translatomeandtranscriptome co-profiling reveals a role of TPRXs in human zygotic genome activation.Science.2022Sep8:eabo7923.
2.Yan J#, Qin Y#,Zhao H#,Sun Y, Gong F, Li R,SunX,LingX,LiH,HaoC,TanJ, YangJ,Zhu Y,Liu F, Chen D, Wei D, Lu J, Ni T, Zhou W, Wu K,Gao Y,Shi Y, Lu Y, Zhang T, Wu W, Ma X,MaH,FuJ, Zhang J, Meng Q, Zhang H, Legro RS, Chen ZJ*. LiveBirthwithor withoutPreimplantationGeneticTesting for Aneuploidy.N Engl J Med. 2021 Nov 25;385(22):2047-2058
3. Chen X#, Ke Y#, Wu K#,Zhao H#,Sun Y, Gao L, LiuZ,ZhangJ, Tao W, HouZ,LiuH,LiuJ*,Chen ZJ*. Key role for CTCF in establishingchromatinstructurein humanembryos.Nature.2019Dec;576(7786):306-310.
4. Song J#, Zhao R#, Zhang Y#, Lu M, Liu P, Li T, Li C, Yu R, Chen X, Yang H, Zhang X, Su Y, Han Y, Sun D, Zhou Q, Hou Z, Liu W, Gao X, Tao W, Zhang J, Wang J, Qin Y, Wang H, Wu K*, Wu J*, Chen ZJ*,Zhao H*. 3D post-implantation co-culture of human embryo and endometrium.Cell Stem Cell. 2025 Dec 23:S1934-5909(25)00436-9.
5. Zhang C#, Zheng W#, Zhang H#, Zhao S, Hu H, Xu X, Wan X, Sun J, Su W, Wang Y, Cui Y, Yang B, Yin C, Zhang X, Li C, Zhang X, Zhang C, Wang Z, Yuan Y, Liu L, Meng F, Zhang J, Cao Y, Gao Y, Zhao S, Gong F, Wu K, Zhang F, Tang S*, Lin G*,Zhao H*, Chen ZJ. Genetic architecture and phenotypic diversity of oocyte and early embryo competence defects in female infertility.Nat Med. 2025 Oct 16.
6. Gao X#, Zhao S#, Du Y#, Yang Z#, Tian Y#, Zhao J#, Yuan X, Santos BR, Wei D, Cui L, Yan J, Qin Y, Shi Y, Tang R, Sun Y, Hu J, Ding L, Song X, Ha L, Li J, Zhang H, Spritzer PM*, Yildiz BO*, Stener-Victorin E*, Yong EL*, Ou XH*, Legro RS*,Zhao H*, Chen ZJ*. Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes.Nat Med. 2025 Oct 29.
7.Zhao H#*, Xu Y#, Xue B#, Zhao S#, Zhang M#, Wu XK, Wang T, Wen Y, Li S, Zhang Q, Yang Z, Sun H, Pan T, Lian Y, Gao X, Gao C, Wang Z, Wu C, Zhang C, Jian X, Peng L, Zhang X, Wang B, Wei L, He Y, Xia D, Wu Z, Yang Q, Sun Y, Ding Y, Du S, Xia G, Jing Y, Xu H, Shi W, Liu J, He L, Chen ZJ, Cao Y*, Li Z*, Shi Y*. Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.Nat Genet. 2025 Nov;57(11):2669-2681.
8. Wang Q#, Zhang C#, Dang Y, Sun J, Zou Z, Li C, Ma S, Li Z, Liu H, Ma X, Yang Z, Wang L, Wu K, Chen ZJ*, Xie W*,Zhao H*. Maternal factor OTX2 regulates human embryonic genome activation and early development.Nat Genet. 2025 Nov;57(11):2772-2784.
9. Liu Y#, Dong Y#, Jiang Y, Han S, Liu X, Xu X, Zhu A, Zhao Z, Gao Y, Zou Y, Zhang C, Bian Y, Zhang Y, Liu J, Zhao S*,Zhao H*, Chen ZJ. Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.Cell Metab.2025 Feb 11; S1550-4131(25)00014-2.
10. Zhang Y#, Chen ZJ*,Zhao H*. Polycystic ovary syndrome: A metabolic disorder with therapeutic opportunities.Cell Metab. 2025 Oct 7;37(10):1932-1949.
11. Qin L#, Sun T#, Li X#, Zhao S#, Liu Z, Zhang C, Jin C, Xu Y, Gao X, Cao Y, Wang J, Han T, Yan L, Song J, Zhang F, Liu F, Zhang Y, Huang Y, Song Y, Liu Y, Zhang J, Zhang X, Yao Z, Chen H, Zhang Z, Zhao S, Feng Y, Zhang YN, Yu Q, Cao F, Zhao L, Xie L, Geng L*, Feng Q*,Zhao H*, Chen ZJ*. Population-level analyses identify host and environmental variables influencing the vaginal microbiome.Signal Transduct Target Ther.2025 Feb 19;10(1):64.
12. Wei D#, Sun Y#,Zhao H#,Yan J#, Zhou H#, Gong F#, Zhang A, Wang Z, Jin L, Bao H, Zhao S, Xiao Z, Qin Y, Geng L, Cui L, Sheng Y, Sun M, Liu P, Ding L, Liu H, Wu K, Li Y, Lu Y, Xu B, Xu B, Zhang L, Zhang H, Legro RS, Chen ZJ*. Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial.BMJ.2025 Jan 29;388:e081474.
13.Zhang H#, Chen T#, Wu K#, Hou Z#, ZhaoS, ZhangC,Gao Y, GaoM,ChenZJ*,Zhao H*.Dominant mutations in CHK1 cause pronuclear fusion failure andzygotearrestthatcanberescuedbyCHK1 inhibitor.Cell Res.2021 Jul;31(7):814-817
14. Wu K#, Chen T#, HuangS, Zhong C, Yan J, Zhang X,LiJ,Gao Y*,Zhao H*,ChenZJ*.Mitochondrial replacement by pre-pronuclear transfer in human embryos.Cell Res.2017Jun;27(6):834-837.
15. Zhang Y#, HanS#, Liu C, Zheng Y, Li H, Gao F,Bian Y, LiuX,LiuH,HuS,Li Y,ChenZJ*,ZhaoS*,Zhao H*. THADA inhibition in mice protects against type 2 diabetes mellitus byimprovingpancreatic β-cell function and preserving β-cell mass.Nat Commun.2023Feb23;14(1):1020.
