姓名：郭婷
邮箱：gtlyp2008@126.com
个人主页：http://faculty.sdu.edu.cn/guoting1/zh_CN/index.htm
个人简介/Personal resume
郭婷，医学博士，副主任医师，教授，博士生导师。山东省优青，泰山学者青年专家，山东大学齐鲁青年学者。围绕女性卵巢储备建立和维持的调控机制，开展病理性卵巢衰老的遗传环境病因及干预研究，绘制早发性卵巢功能不全（POI）的遗传变异图谱，累计鉴定30个POI致病基因，为POI遗传病因诊断和个体化干预奠定基础。作为第一/通讯作者在Nature Medicine、Endocrine Reviews、Journal of Clinical Investigation、Journal of Hazardous Materials、Genetics in Medicine等杂志发表SCI论文30余篇，获批中国发明专利4件。参与译写《Human Reproductive and Prenatal Genetics》(2nd Edition, 2023)、《步步精进: 临床胚胎学与辅助生殖技术》等书籍。多次受邀在国际生育联盟大会（IFFS 2023）、亚太生殖大会（ASPIRE 2016，2021）等做学术报告。主持国家重点研发计划子课题2项、国家自然科学基金项目3项、山东省重点研发计划1项。荣获山东省医学会青年科技奖一等奖（首届）、国家妇幼健康科学技术奖一等奖、张丽珠生殖医学青年创新奖、第二十届中国青年女科学家团队奖等奖项。兼任中国妇幼健康协会生殖内分泌专业委员会委员、中国遗传学会青年委员会委员、山东省医师协会妇产科分会委员兼秘书，担任Journal of Genetics and Genomics、Cell Proliferation等杂志青年编委。
研究领域/Research direction
面向生育力保护和促进的国家战略需求，围绕最常见的女性生殖衰老性疾病—早发性卵巢功能不全（POI）和早绝经（EM）开展病因机制解析和干预策略研发。利用国际最具规模的卵巢衰老专病队列和前瞻性随访队列，通过多元化遗传数据分析、表型数据机器学习等方法，结合系统的细胞和分子生物学研究框架，从遗传、环境、医源性因素等多维度解析卵巢衰老的高危因素和干预方案。
主要课题方向：
1. 病理性卵巢衰老的遗传致病机制
2. 卵巢衰老的遗传环境交互作用
3. 卵巢衰老表型谱及其与机体衰老的相关性
4. 女性生育力保护和保存的新技术研发
招生信息/Enrollment information
1. 一级学科：临床医学
2. 二级学科：妇产科学
3. 学科方向：妇产科学/生殖医学
4. 招生类型：学术型博士，学术/专业型硕士
荣誉奖励/Honors & Awards
张丽珠生殖医学青年创新奖，2024年
山东省医学会青年科技奖一等奖，2023年
第二十届中国青年女科学家奖团队奖，2025年
中国妇幼健康科学技术奖一等奖，2023年
山东医学科技奖一等奖，2017年
山东大学附属生殖医院（妇儿与生殖健康研究院）优秀临床指导教师，2024年
代表性论文/Representative publications
1. Ke Hanni#, Tang Shuyan#, Guo Ting#, Hou Dong, Jiao Xue, Li Shan, Luo Wei, Xu Bingying, Zhao Shidou, Li Guangyu, Zhang Xiaoxi, Xu Shuhua, Wang Lingbo, Wu Yanhua, Wang Jiucun, Zhang Feng*, Qin Yingying*, Jin Li*, Chen Zi-Jiang*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023, 29(2):483-492.
2. Guo Ting#*, Liu Hongyuan, Xu Bingying, Qi Yu, Xu Keyan, Wu Xinyi, He Xinmiao, Qin Yingying*, Chen Zi-Jiang*. Epidemiology, genetic etiology and intervention of premature ovarian insufficiency. Endocrine Reviews. 2025:bnaf011.
3. Cao Zifeng, Wu Xinyi, Liu Hongyuan, Xu Keyan, Yang Yehuan, Yang Mengting, Wei Daimin, Zhao Shidou, Jiao Xue, Zhao Qi, Zheng Ruimin*, Qin Yingying*, Guo Ting*, Chen Zi-Jiang. Associations of long-term exposure to fine particulate matter and its components with ovarian aging: Evidence from a cross-sectional study in China. Journal of Hazardous Materials. 2025 May 12;494:138589.
4. Tang Shuyan#, Guo Ting#, Song Chengcheng#, Wang Lingbo#, Zhang Jun#, Rajkovic Aleksandar, Lin Xiaoqi, Chen Shiling, Liu Yujun, Tian Weidong, Wu Bangguo, Wang Shixuan, Wang Wenwen, Lai Yunhui, Wang Ao, Xu Shuhua, Jin Li, Ke Hanni, Zhao Shidou, Li Yan*, Qin Yingying*, Zhang Feng*, Chen Zi-Jiang*. MGA loss-of-function variants cause premature ovarian insufficiency. Journal of Clinical Investigation. 2024, 15;134(22):e183758.
5. He Xinmiao#, Chang Xinyue#, Zhuang Shuning#, Liu Jianing, Wang Yuteng, Qin Yingying, Guo Ting*. Genome-wide DNA methylation profile and predictive biomarkers in premature ovarian insufficiency. Journal of Genetics and Genomics. 2025 Apr;52(4):596-599.
6. Zhang Qian, Zhang Wenzhe, Wu Xinyi, Ke Hanni, Qin Yingying, Zhao Shidou*, and Guo Ting*. Homozygous missense variant in MEIOSIN causes premature ovarian insufficiency. Human Reproduction. 2023, 38(Supplement_2):ii47-ii56.
7. Xu Bingying, Li Zhuqing, Li Shan, Ke Hanni, Zhang Qian, Qin Yingying, Guo Ting*. Pathogenic variants in TSC2 might cause premature ovarian insufficiency through activated mTOR induced hyperactivation of primordial follicles. Fertility and Sterility. 2022, 118(6):1139-1149.
8. Hou Dong, Yao Chencheng, Xu Bingying, Luo Wei, Ke Hanni, Li Zheng, Qin Yingying, Guo Ting*. Variations of C14ORF39 and SYCE1 identified in idiopathic premature ovarian insufficiency and nonobstructive azoospermia. Journal of Clinical Endocrinology & Metabolism. 2022, 107(3):724-734.
9. Zhang Qian, Tao Chengqiu, Gao Shuchang, Li Shan, Xu Bingying, Ke Hanni, Wang Yiyang, Zhang Feng, Qin Yingying, Zhang Ling*, Guo Ting*. Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing. Journal of Clinical Endocrinology & Metabolism. 2022, 107(9):2589-2597.
10. Zhao Simin, Huang Chengzi, Yang Yajuan, Xu Weiwei, Yu Yongze, Wen Canxin, Cao Lili, Gao Fei, Qin Yingying, Chen Zi-Jiang, Guo Ting*, Zhao Shidou*. DNA repair protein FANCD2 has both ubiquitination-dependent and -independent functions during germ cell development. Journal of Biological Chemistry. 2023, 299(3):102905.
11. Qi Yu #, Wang Yiyang #, Li Weilin, Zhuang Shuning, Li Shan, Xu Keyan, Qin Yingying*, Guo Ting *. Pathogenic bi-allelic variants of meiotic ZMM complex gene SPO16 in premature ovarian insufficiency. Clinical Genetics. 2023, 104(4):486-490.
12. Yao Chencheng, Hou Dong, Ji Zhiyong, Pang Dongmei, Li Peng, Tian Ruhui, Zhang Yuxiang, Ou Ningjing, Bai Haowei, Zhi Erlei, Huang Yuhua, Qin Yingying, Zhao Jingpeng, Wang Chenchen, Zhou Zhi, Guo Ting*, Li Zheng*. Bi-allelic SPATA22 variants cause premature ovarian insufficiency and nonobstructive azoospermia due to meiotic arrest. Clinical Genetics. 2022, 101(5-6):507-516.
13. Luo Wei, Ke Hanni, Tang Shuyan, Jiao Xue, Li Zhuqing, Zhao Shidou, Zhang Feng, Guo Ting*, Qin Yingying *. Next-generation sequencing of 500 POI patients identified novel responsible monogenic and oligogenic variants. Journal of Ovarian Research. 2023, 16(1):39.
