姓名：郭婷
邮箱：gtlyp2008@126.com
个人主页：http://faculty.sdu.edu.cn/guoting1/zh_CN/index.htm
个人简介/Personal resume
郭婷，医学博士，主任医师，教授，博士生导师。国家“万人计划”青年拔尖人才，山东省优青，泰山学者青年专家，山东大学杰出中青年学者。围绕女性卵巢储备建立和维持的调控机制，开展病理性卵巢衰老的遗传-环境病因及干预研究，绘制早发性卵巢功能不全（POI）的遗传变异图谱，累计鉴定30余个POI致病基因，为POI遗传病因诊断和个体化干预奠定基础。作为第一/通讯作者在BMJ、Nature Medicine、Science Bulletin、Endocrine Reviews、Journal of Clinical Investigation、Journal of Hazardous Materials 等杂志发表SCI论文30余篇，获批中国发明专利4件。参与译写《Human Reproductive and Prenatal Genetics》(2nd Edition, 2023)、《步步精进: 临床胚胎学与辅助生殖技术》等书籍。多次受邀在国际生育联盟大会（IFFS 2023）、亚太生殖大会（ASPIRE 2016，2021）等做学术报告。主持国家重点研发计划子课题2项、国家自然科学基金项目4项、山东省重点研发计划1项。荣获山东省医学会青年科技奖一等奖（首届）、国家妇幼健康科学技术奖一等奖、张丽珠生殖医学青年创新奖、第二十届中国青年女科学家团队奖等奖项。兼任中国医师协会妇产科医师分会委员、中国妇幼健康协会生殖内分泌专业委员会委员、中国遗传学会青年委员会委员、山东省医师协会妇产科分会委员兼秘书，担任Journal of Genetics and Genomics、Cell Proliferation等杂志青年编委。
研究领域/Research direction
面向生育力保护和促进的国家战略需求，围绕最常见的女性生殖衰老性疾病—早发性卵巢功能不全（POI）和早绝经（EM）开展病因机制解析和干预策略研发。利用国际最具规模的卵巢衰老专病队列和前瞻性随访队列，通过多元化遗传数据分析、表型数据机器学习等方法，结合系统的细胞和分子生物学研究框架，从遗传、环境、医源性因素等多维度解析卵巢衰老的高危因素和干预方案
主要课题方向：
1. 病理性卵巢衰老的遗传致病机制
2. 卵巢衰老的遗传环境交互作用
3. 卵巢衰老表型谱及其与机体衰老的相关性
4. 女性生育力保护和保存的新技术研发
招生信息/Enrollment information
1. 一级学科：临床医学
2. 二级学科：妇产科学
3. 学科方向：妇产科学/生殖医学
4. 招生类型：学术型博士，学术/专业型硕士
荣誉奖励/Honors & Awards
1. 张丽珠生殖医学青年创新奖
2. 山东省医学会青年科技奖一等奖（首届）
3. 中国妇幼健康科学技术奖一等奖
4. 第二十届中国青年女科学家奖团队奖
5. 第十一届全国大学生医学创新大赛暨“一带一路”国际竞赛总决算本科院校基础临床赛道国家级金奖（指导教师）
6. 山东大学先进医务工作者
7. 山东大学附属生殖医院（妇儿与生殖健康研究院）优秀临床指导教师
代表性论文/Representative publications
1. Ke Hanni#, Tang Shuyan#, Guo Ting#, Hou Dong, Jiao Xue, Li Shan, Luo Wei, Xu Bingying, Zhao Shidou, Li Guangyu, Zhang Xiaoxi, Xu Shuhua, Wang Lingbo, Wu Yanhua, Wang Jiucun, Zhang Feng*, Qin Yingying*, Jin Li*, Chen Zi-Jiang*. Landscape of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023;29(2):483-492.（IF: 58.7）
2. Wei Daimin#, Qin Yingying#, Sun Yun#, Yan Junhao#, Zhao Han#, Guan Yichun#, Tan Jichun#, Guo Ting#, Wang Ze#, Gong Fei, Hao Cuifang, Ma Xiang, Zhang Cuilian, Zhang Aijun, Geng Ling, Sun Mei, Li Xiufang, Ling Xiufeng, Lu Qun, Bao Hongchu, Chao Lan, Huang Wei, Shi Qinghua, Zhao Junli, Lu Yao, Wu Sheling, Zhang Shunji, Wang Jing, Guo Meiling, Sun Xiaoxi, Ma Yanlin, Wu Qiongfang, Li Yanping, Ou Xianghong, Fang Zhou, Chen Jiao, Hao Guimin, Zhang Heping, Legro Richard S, Chen Zi-Jiang*, PnROVE Study Group. Natural ovulation versus programmed regimens before frozen embryo transfer in ovulatory women: multicentre, randomised clinical trial. BMJ. 2026;392:e087045.（IF: 55.1）
3. Guo Ting#*, Liu Hongyuan, Xu Bingying, Qi Yu, Xu Keyan, Wu Xinyi, He Xinmiao, Qin Yingying*, Chen Zi-Jiang*. Epidemiology, Genetic Etiology, and Intervention of Premature Ovarian Insufficiency. Endocrine Reviews. 2025;46(5):621-651.（IF: 23.9）
4. Guo Ting#*, Wu Xinyi#, Liu Peihao, Cao Zifeng, Xu Keyan, Yang Li, Huang Guangmei, Ma Qianqian, Yang Xiaomin, Gao Xin, Yang Yehuan, Yang Yilin, Yang Yajuan, Jiao Xue, Zhao Shidou, Wei Daimin, Yan Junhao, Zhu Dongshan, Zheng Ruimin*, Qin Yingying*, Chen Zi-Jiang. Menopause status and modifiable risk factors for early menopause in China: a nationwide cross-sectional study on geographical disparities. Science Bulletin. 2026;71(10):2433-2437.（IF:20.7）
5. Tang Shuyan#*, Guo Ting#, Song Chengcheng#, Wang Lingbo#, Zhang Jun#, Rajkovic Aleksandar, Lin Xiaoqi, Chen Shiling, Liu Yujun, Tian Weidong, Wu Bangguo, Wang Shixuan, Wang Wenwen, Lai Yunhui, Wang Ao, Xu Shuhua, Jin Li, Ke Hanni, Zhao Shidou, Li Yan*, Qin Yingying*, Zhang Feng*, Chen Zi-Jiang*. MGA loss-of-function variants cause premature ovarian insufficiency. Journal of Clinical Investigation. 2024;134(22):e183758.（IF: 13.6）
6. Cao Zifeng#, Wu Xinyi, Liu Hongyuan, Xu Keyan, Yang Yehuan, Yang Manting, Wei Daimin, Zhao Shidou, Jiao Xue, Zhao Qi, Zheng Ruimin*, Qin Yingying*, Guo Ting*, Chen Zi-Jiang. Associations of long-term exposure to fine particulate matter and its components with ovarian aging: Evidence from a cross-sectional study in China. Journal of Hazardous Materials. 2025;494:138589.（IF: 11.3）
7. Guo Ting#*, Qin Yingying*. Translating genetic testing into fertility care. Science China Life Sciences. 2026. doi: 10.1007/s11427-026-3345-x.（IF:9.6）
8. Wang Yuteng#, Qi Yu#, Cao Zifeng, Xu Keyan, Xia Ruoliu, Zhao Shigang, Cui Linlin, Wei Daimin, Zhao Han, Tang Shuyan*, Qin Yingying*, Guo Ting*. Social isolation and loneliness associate with early menopause and mortality in women: a UK Biobank cohort study. BMC Medicine. 2026. doi: 10.1186/s12916-026-05027-z.（IF:9.1）
9. Wang Yiyang#, Qi Yu#, Xu Keyan#, Tang Shuyan, Tan Luyi, Xu Bingying, Wang Ying, Zhang Shuxian, Zou Yang, Gao Yuan, Zhang Chunmei, Liang Xin, Jiao Xue, Zhao Shidou, Zhao Han, Wang Shixuan, Qin Yingying*, Guo Ting*, Chen Zi-Jiang. MEI4 variations drive female reproductive disorders via impaired oocyte abundance and developmental potential. Journal of Genetics and Genomics. 2026;53(4):615-629.（IF: 7.9）
10. Wu Xinyi#, Zhang Qian#, Li Chang#, Zhuang Shuning, Liu Hongyuan, Jiao Xue, Zhao Shidou, Qin Yingying, Guo Ting*. Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination. Communications Biology. 2025;8:1104.（IF:5.8）
