姓名：郭婷
邮箱：gtlyp2008@126.com
个人简介/Personal resume
医学博士，副主任医师，临床副教授，硕士研究生导师。主要从事早发性卵巢功能不全（POI）的遗传学致病机制研究。从减数分裂、DNA损伤修复及卵泡激活与发育等影响卵巢储备的生理过程出发，寻找致病基因，并借助功能实验阐明基因突变参与POI发生的分子机制。相关成果发表于医学及遗传学权威期刊Nature Medicine、Genetics in Medicine、PLoS Genetics、Human Molecular Genetics、Fertility and Sterility和The Journal of Clinical Endocrinology & Metabolism等。近5年以通讯作者或第一作者发表SCI论文15篇，主持国家自然科学基金项目2项，作为课题负责人参与国家重点研发计划2项，主持山东省重点研发计划1项、山东省优秀青年基金1项，获批泰山学者青年专家，2022年获首届山东省医学会青年科技一等奖，兼任妇幼健康研究会生殖内分泌学专业委员会委员。
研究领域/Research direction
本课题组研究：早发性卵巢功能不全（POI）的遗传学致病机制
主要研究课题：
1. 通过全外显子组测序及全基因组测序筛查POI致病变异。
2. 关注DNA损伤修复基因、减数分裂相关基因、线粒体功能相关基因及卵泡激活与发育相关基因在POI中的致病性及作用机制。
3. 从遗传变异出发，结合多模态数据，利用机器学习算法，构建卵巢衰老预测模型，并尝试开展个体化预警和干预策略。
招生信息/Enrollment information
招生学科（一级和二级学科）：临床医学/妇产科学
学科方向：妇产科学、生殖医学
荣誉奖励/Honors & Awards
2022年山东省医学会青年科技一等奖
代表性论文/Representative publications
1.Hanni Ke#, Shuyan Tang#, Ting Guo#, Dong Hou, Xue Jiao, Shan Li, Wei Luo, Bingying Xu, Shidou Zhao, Guangyu Li, Xiaoxi Zhang, Shuhua Xu, Lingbo Wang, Yanhua Wu, Jiucun Wang, Feng Zhang, Yingying Qin, Li Jin, Zi-Jiang Chen. Landscape of pathogenic mutations in premature ovarian insufficiency. Nature Medicine. 2023.
2.Bingying Xu , Zhuqing Li , Shan Li , Hanni Ke , Qian Zhang , Yingying Qin, Ting Guo*. Pathogenic variants in TSC2 might cause premature ovarian insufficiency through activated mTOR induced hyperactivation of primordial follicles. Fertility and Sterility. 2022, 118(6):1139-1149.
3.Hou Dong, Yao Chencheng, Xu Bingying, Luo Wei, Ke Hanni, Li Zheng, Qin Yingying, Guo Ting*. Variations of C14ORF39 and SYCE1 identified in idiopathic premature ovarian insufficiency and nonobstructive azoospermia. Journal of Clinical Endocrinology & Metabolism. 2022, 107(3):724-734.
4.Qian Zhang, Chengqiu Tao, Shuchang Gao, Shan Li, Bingying Xu, Hanni Ke, Yiyang Wang, Feng Zhang, Yingying Qin, Ling Zhang*, Ting Guo*. Homozygous variant in KASH5 causes premature ovarian insufficiency by disordered meiotic homologous pairing. Journal of Clinical Endocrinology & Metabolism. 2022, 107(9):2589-2597.
5.Chencheng Yao, Dong Hou, Zhiyong Ji, Dongmei Pang, Peng Li, Ruhui Tian, Yuxiang Zhang, Ningjing Ou, Haowei Bai, Erlei Zhi, Yuhua Huang, Yingying Qin, Jingpeng Zhao, Chenchen Wang, Zhi Zhou, Ting Guo*, Zheng Li*. Bi-allelic SPATA22 variants cause premature ovarian insufficiency and nonobstructive azoospermia due to meiotic arrest. Clinical Genetics.2022, 101(5-6):507-516.
6.Simin Zhao, Chengzi Huang, Yajuan Yang, Weiwei Xu, Yongze Yu, Canxin Wen, Lili Cao, Fei Gao, Yingying Qin, Zi-Jiang Chen, Ting Guo*, Shidou Zhao*. DNA repair protein FANCD2 has both ubiquitination-dependent and -independent functions during germ cell development. Journal of Biological Chemistry. 2023, 12, e102905.
7.Guo Ting, Zhao Shidou, Zhao Shigang, Chen Min, Li Guangyu, Jiao Xue, Wang Zhao, Zhao Yueran, Qin Yingying*, Gao Fei*, Chen Zi-Jiang*. Mutations in MSH5 in primary ovarian insufficiency, Human Molecular Genetics. 2017, 26(8): 1452-1457.
8.Guo Ting (co-first), Zheng Ye, Li Guangyu, Zhao Shidou, Ma Jinlong, Qin Yingying*. Novel pathogenic mutations in minichromosome maintenance complex component 9 (MCM9) responsible for premature ovarian insufficiency. Fertility and Sterility. 2020, 113(4): 845-852.
9.Wang Yiyang, Guo Ting (co-first), Ke Hanni, Zhang Qian, Li Shan, Luo Wei, Qin Yingying. Pathogenic variants of meiotic double strand break (DSB) formation genes PRDM9 and ANKRD31 in premature ovarian insufficiency. Genetics in Medicine. 2021, 23(12):2309-2315.
10. Luo Wei, Guo Ting (co-first), Li Guangyu, Liu Ran, Zhao Shidou, Song Meihui, Zhang Liangran, Wang Shunxin, Chen Zi-Jiang, Qin Yingying*. Variants in homologous recombination genes EXO1 and RAD51 related with premature ovarian insufficiency. Journal of Clinical Endocrinology & Metabolism. 2020, 105(10), e3566–e3574.
