姓名：刘洪彬
邮箱：hongbin_sduivf@email.sdu.edu.cn
个人主页：
https://faculty.sdu.edu.cn/liuhongbin/zh_CN/index.htm
个人简介/Personal resume
中共党员，教授，博士生导师，省级青年专家，山东大学杰出中青年学者，山东大学齐鲁青年学者。主要从事精子发生异常与男性不育发病机制研究及滋阴补肾中药的二次开发和转化研究。在国家自然科学基金 (5项)、国家重点研发计划课题（4项）、山东省重大科技创新工程及自然科学基金（4项）、中国博士后项目(面上、特别)、横向课题（5项）等的资助下， 研究成果在Genome Biology、EMBO Journal、Science Advances、Protein & Cell、Nucleic Acids Research、Advanced Science、Science Bulletin等主流期刊发表论文30余篇，授权国家发明专利12件。荣获全国妇幼健康科学技术奖一等奖、中华医学科技奖一等奖。现任生殖医学与子代健康全国重点实验室（山东大学）和香港中文大学-山东大学生殖遗传联合实验室课题组组长。社会兼职包括中国生理学会生殖科学专业委员会委员、中国解剖学会医学发育生物学分会青年委员、中国细胞生物学生殖细胞分会常委、山东省干细胞学会第一届干细胞技术与临床应用研究专业委员会委员。
研究领域/Research direction
正在开展的课题：
1. 基于本实验室积累的多个基因编辑小鼠模型（cKO、KO、KI），开展生殖细胞减数分裂关键事件（减数分裂启动、同源重组修复、性染色体沉默）等的分子机制研究。
2. 依托实验独立建立的精原干细胞体外培养体系，研究：1）精原干细胞增殖与分化的调控机制；2）减数分裂启动的关键事件；3）基于中药单体库筛选促进生精功能的候选药物。
3. 以临床问题为导向，依托山东大学附属生殖医院和上海交通大学仁济医院男性不育资源库，结合高通量测序和多种基因编辑小鼠模型，阐明男性不育发病机理，为优生遗传提供分子标记。
招生信息/Enrollment information
招生学科（一级和二级学科）：
一级学科：基础医学
二级学科：基础医学
学科方向：细胞生物学（干细胞与生殖）
荣誉奖励/Honors & Awards
1. 山东大学青年学者未来计划
2. 山东大学齐鲁青年学者
3. 山东大学杰出中青年学者
4. 山东省泰山学者青年专家
5. 山东省杰出青年基金获得者
6. 山东省研究生教育课程思政师范教学团队
7. 中华医学科技奖青年科技奖
8. 妇幼健康科学技术奖自然科学奖一等奖
代表性论文/Representative publications
2025年
1）Zhang M, Li M, Li H, Wan Y, Yang S, Ji S, Zhang H, Liu C, Lu G, Jiang X, Liu H*. Dysregulation of N-glycosylation by Rpn1 knockout in spermatocytes induces male infertility via endoplasmic reticulum stress in mice. Int J Biol Sci . 2025 Mar 3;21(5):2360-2379. doi: 10.7150/ijbs.106468. eCollection 2025.
2）Meng L, Xu C, Cao Y, Wu L, Zhu Y, Zou J, Uddin I, Zafar I, Muhammad A, Xing X, Jin RT, He L, Liu H*, Li W, Bao J. Combinatorial tagging generates a multi-purpose knock-in mouse model revealing phase separation-dependent germ granules in RNA homeostasis and germline development. Cell Death Differ. 2025 Apr 23. doi: 10.1038/s41418-025-01495-7.
3）Jie Cen, Xiaochen Yu, Ziqi Wang, Wenbo Liu, Jianze Xu, Qian Fang, Fei Gao*, Yongzhi Cao*, Hongbin Liu*. YKT6 is essential for male fertility by promoting meiosis progression during spermatogenesis of mice. Cell Prolif. 2025 Jun 18:e70079. doi: 10.1111/cpr.70079.
4）Xiaochen Yu*, Jie Cen*, Yaxuan Zhang, Tongtong Li, Mingyu Zhang, Fei Gao, Hongbin Liu, Yongzhi Cao. UBE2J2 is essential for the progression of meiosis prophase I during spermatogenesis in mice. iScience (Accept)
2024年
1. Mengyue Wang, Jiayi Li, Bowen Liu, Zhiming Shen, Min Chen, Xiuhong Cui, Hongbin Liu*, Fei Gao, Han Zhao. TRAPPC2l Participates in Male Germ Cell Development by Regulating Cell Division. Cell Prolif. 2025 Jun;58(6):e13810. doi: 10.1111/cpr.13810.
2. Ziyou Bao, Yan Wang, Renxue Wang, Fan Dong, Tongtong Li, Wai-Yee Chan, Zi-Jiang Chen, Gang Lu, Hongbin Liu*, Xiangfeng Chen. Pathogenic TDRD12 variants cause defective piRNA pathway and male infertility in humans and mice. Journal of Genetics and Genomics. 2024 Nov;55(11):1322-1326.
3. Wang S, Cai Y, Li T, Wang Y, Bao Z, Wang R, Qin J, Wang Z, Liu Y, Liu Z, Chan WY, Chen X, Lu G, Chen ZJ, Huang T, Liu H*. CWF19L2 is Essential for Male Fertility and Spermatogenesis by Regulating Alternative Splicing. Adv Sci (Weinh). 2024 Jun 18:e2403866.
4. Liu Y, Li T, Shi M, Wan Y, Li H, Zhang M, Wang Z, Wang S, Lv Y, Lu G, Liu H, Zhang H, Huang T. MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice. J Transl Med. 2024 Mar 5;22(1):240.
5. Wang Z, Li T, Liu D, Li M, Liu S, Yu X, Li H, Song H, Zhao W, Liu Z, Chen X, Lu G, Chen ZJ, Huang T, Liu H*. The deubiquitinase cofactor UAF1 interacts with USP1 and plays an essential role in spermiogenesis. iScience. 2024 Mar 11;27(4):109456.
2023年
1. Wang Z#, Fang K, Wan Y, Yin Y, Li M, Xu K, Li T, Cao Y, Lv Y, Lu G, Liu H, Huang T*. TTC6-Mediated Stabilization of the Flagellum Annulus Ensures the Rapid and Directed Motion of Sperm. Cells. 2023 Aug 18;12(16):2091.
2. Wan Y#, Yang S#, Li T, Cai Y, Wu X, Zhang M, Muhammad T, Huang T, Lv Y, Chan WY, Lu G, Li J, Sha QQ*, Chen ZJ*, Liu H*. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance. Nucleic Acids Res. 2023 Nov 27;51(21):11652-11667.
3. Liu C#, Wang Q#, Gu L#, Wang X#, Yin Y#, Huang T, Xiao S, Zhang S, Wang F, Zhou T, Xu G, Wang L, Dong F, Jiang J, Luo M, Li J, Zhang H, Chen Z-J, Ji W*, Ji B*, Liu H*, Li W*. CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement. Current Biology. Available online 25 July 2023. 33,1-18.
4. Muhammad T#, Wan Y#, Lv Y, Li H, Naushad W, Chan W-Y, Lu G*, Chen Z-J*, Liu H*. Maternal Obesity: A potential disruptor of female fertility and current interventions to reduce associated risks. Obesity Reviews. 2023 Oct;24(10):e13603.
5. Wang M#, Kang J, Shen Z, Hu Y, Chen M, Cui X, Liu H*, Gao F*. CCDC189 is involved in sperm flagellum formation by interacting with CABCOCO1. National Science Review. nwad181, https://doi.org/10.1093/nsr/nwad181. Published:26 June 2023.
6. Huang T#, Wu X#, Wang S, Bao Z, Wan Y, Wang Z, Li M, Yu X, Lv Y, Liu Z, Chen X, Chan W-Y, Gao F, Lu G*, Chen Z-J*, Liu H*. SPIDR is Required for Homologous Recombination During Mammalian Meiosis. Nucleic Acids Research. 2023 May 8;51(8):3855-3868.
7. Xu K#, Su X#, Fang K#, Lv Y , Huang T, Li M, Wang Z , Yin Y, Muhammad T, Liu S, Chen X, Jiang J, Li J, Chan W-Y, Ma J, Lu G*, Chen Z-J*, Liu H*.The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice. eLife. 2023 Mar 21;12:e83129.
8. Qin J# , Huang T #, Wang Z # , Zhang X , Wang J, Dang Q, Cui D, Wang X, Zhai Y, Zhao L, Lu G, Shao C , Li S, Liu H*, Liu Z*. Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation . Cell Death and Differentiation. 2023 Jan;30(1):184-194.
2022年
1. Yuan S#, Huang T*#, Bao Z#, Wang S#, Wu X#, Liu J*, Liu H*, Chen Z-J*. The histone modification reader ZCWPW1 promotes double‑strand break repair by regulating cross‑talk of histone modifications and chromatin accessibility at meiotic hotspots. Genome Biology. 2022 Sep 6;23(1):187.
2. Lv Y# , Lu G# , Cai Y#, Su R# , Liang L, Wang X, Mu W, He X, Huang T, Ma J, Zhao Y, Chen Z-J*, Xue Y*, Liu H*, Chan W-Y*. RBM46 is essential for gametogenesis and functions in posttranscriptional roles affecting meiotic cohesin subunits. Protein & Cell. 2022 Sep 14;14(1):51-63.
3. Yin Y#, Mu W, Yu X, Wang Z, Xu K, Wu X, Cai Y, Zhang M, Lu G, Chan W-Y, Ma J, Huang T*, Liu H*. LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse. International Journal of Molecular Sciences. 2022 Jul 31;23(15):8525.
4. Wan Y#, Muhammad T#, Huang T, Lv Y, Sha Q, Yang S, Lu G, Chan W-Y, Ma J, Liu H*. IGF2 reduces meiotic defects in oocytes from obese mice and improves embryonic developmental competency. Reproductive Biology and Endocrinology. 2022 Jul 14;20(1):101.
5. Yu X#, Lu S, Yuan M, Ma G, Li X, Zhang T, Gao S, Wei D, Chen Z-J, Liu H*, Zhang H*. Does ICSI outcome in obstructive azoospermia differ according to the origin of retrieved spermatozoa or the cause of epididymal obstruction? A comparative study. International Urology and Nephrology. 2022 Dec;54(12):3087-3095.
2021年
1. Liu C#, Liu H#, Zhang H#, Wang L#, Li M, Cai F, Wang X, Wang L, Zhang R,Yang S, Liu W, Liang Y, Wang L, Song X, Su S, Gao H, Jiang J, Li J, Luo M, Gao F, Chen Q, Li W*, Chen Z-J*. Paternal USP26 mutations raise Klinefelter Syndrome risk in the offspring of mice and humans. EMBO Journal. 2021 Jul 1;40(13):e106864.
2. Wu B#, Yu X#, Liu C, Wang L, Huang T, Lu G, Chen Z-J, Li W*, Liu H*. Essential role of CFAP53 in sperm flagellum biogenesis. Frontiers in Cell and Developmental Biology. 2021 May 28;9:676910.
3. Yu X#, Li M#, Cai F, Yang S, Liu H*, Zhang H*. A new TEX11 mutation causes azoospermia and testicular meiotic arrest. Asian Journal of Andrology. Sep-Oct 2021;23(5):510-515.
2020年
1. Muhammad T#, Wan Y#, Sha Q, Wang J, Huang T, Cao Y, Li M, Yu X, Yin Y, Chan W-Y, Chen Z-J, You L*, Lu G*, Liu H*. IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice. Aging-US. 2020 Dec 9;13(2):2118-2134.
2. Shang Y#, Huang T#, Liu H, Liu Y, Liang H, Yu X, Li M, Zhai B 2, Yang X, Wei Y, Wang G, Chen Z-J*, Wang S*, Zhang L*. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Nucleic Acids Research. 2020 Jul 9;48(12):6624-6639.
3. Huang T#, Yin Y#, Liu C, Li M, Yu X, Wang X, Zhang H, Muhammad T, Gao F, Li W, Chen Z-J*, Liu H*, Ma J*. Absence of Murine CFAP61 Causes Male Infertility due to Multiple Morphological Abnormalities of the Flagella. Science Bulletin. 2020 May 30;65(10);854-864.
4. Huang T#, Yuan S#, Gao L, Li M, Yu X, Zhang J, Yin Y, Liu C, Zhang C, Lu G, Li W, Liu J*, Chen Z-J*, Liu H*. The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double strand break repair. eLife. 2020 May 6;9. pii: e53459.
5. Muhammad T#, Li M#, Wang J, Huang T, Zhao S, Zhao H, Liu H*, Chen Z-J*. Roles of insulin-like growth factor II in regulating female reproductive physiology. Science China-Life Sciences. 2020 Jun;63(6);849-865.
