姓名：焦雪
邮箱：jiaoxue@sdu.edu.cn
jx_jiao@126.com
个人主页：
https://faculty.sdu.edu.cn/jiaoxue/zh_CN/index.htm
个人简介/Personal resume
焦雪，女，研究员，医学博士，美国国立卫生研究院（NIH）博士后。长期从事生殖障碍性疾病免疫致病机制及早期诊治研究，以第一/通讯作者在Trends Endocrinol Metab、Clin Transl Med、Mucosal Immunol、Fertil Steril、Thyroid、J Clin Endocrinol Metab、Hum Reprod等国际专业杂志发表论文近20篇。承担多项国家及省部级科研项目，作为课题负责人及学术骨干参与国家重点研发计划3项，主持国自然基金项目3项、省自然基金项目2项、国家博士后基金面上项目1项；山东省优秀青年科学基金项目获得者，入选“泰山学者青年专家”、“山东大学青年学者（未来计划）”，荣获ISIR Young Investigator Award、山东医学科技奖一等奖（第四位），现任山东省免疫协会委员。
研究领域/Research direction
1. 早发性卵巢功能不全（POI）临床及致病机制研究
2. 自身免疫因素在生殖障碍性疾病中的作用及机制研究
招生信息/Enrollment information
1. 一级学科：临床医学
2. 二级学科：妇产科学
3. 学科方向：妇产科学/生殖医学
荣誉奖励/Honors & Awards
2022年 山东省优秀青年科学基金项目
2022年 山东省泰山学者青年专家
2019年 ISIR Young Investigator Award
2017年 山东大学青年学者（未来计划）
2017年 山东医学科技奖一等奖（第四位）
代表性论文/Representative publications
1. Liu W, Sheng S, Zhu C, Li C, Zou Y, Yang C, Chen ZJ, Wang F, Jiao X*. Increased NKG2A+CD8+ T-cell exhaustion in patients with adenomyosis. Mucosal Immunol 2023.
2. Zhang W, Xu S, Zhang R, Li Z, Li N, Zhang X, Lu Y, Bian Y, Yang P, Qin Y, Jiao X*. The TH22-mediated IL-22 deficiency associated with premature ovarian insufficiency. Am J Reprod Immunol 2023.
3. Li N, Lu Y, Si P, Li Z, Qin Y, Jiao X*. The impact of moderately high preconception TSH levels on ovarian reserve among euthyroid infertile women undergoing ART. Thyroid 2022;32(7):841-848.
4. Li Z#, Xu S#, Luo W, Hu J, Zhang T, Jiao X*, Qin Y*, Association between thyroid autoimmunity and the decline of ovarian reserve in euthyroid women, Reprod BioMed Online 2022;45(3):615-622.
5. Li N#, Li Z, Fang F, Zhu C, Zhang W, Lu Y, Zhang R, Si P, Bian Y, Qin Y and Jiao X*. Two distinct resident macrophage populations coexist in the ovary. Front Immunol 2022;13:1007711.
6. Meng T#, Zhang W#, Zhang R, Li J, Gao Y, Qin Y, Jiao X*. Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients With FOXL2 Mutations. Front Endocrinol 2022;13:829153.
7. Liu XY#, Xu JX#, Bi LX, Liu PH*, Jiao X*. Growth hormone cotreatment for low-prognosis patients according to the POSEIDON criteria. Front Endocrinol 2021;12:790160.
8. Jiao X#, Meng T#, Zhai Y, Zhao L, Luo W, Liu P, Qin Y*. Ovarian reserve markers in premature ovarian insufficiency: within different clinical stages and different etiologies. Front Endocrinol 2021;12: 601752.
9. Zhu C, Luo W, Li Z, Zhang X, Hu J, Zhao S, Jiao X*, Qin Y. New theca-cell marker insulin-like factor 3 is associated with premature ovarian insufficiency. Fertil Steril 2021;115 (2), 455-462.
10. Jiao X#, Zhang X#, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ*, Chen W*, Qin Y*. Treg deficiency-mediated TH1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. Clin Transl Med 2021;11(6):e448.
11. Ke H#, Hu JM, Zhao LJ, Ding LL, Jiao X*, Qin Y*. Impact of thyroid autoimmunity on ovarian reserve, pregnancy outcome, and offspring health in euthyroid women following in vitro fertilization/intracytoplasmic sperm injection. 2020, Thyroid 30 (4), 588-597.
12. Liu P#, Zhang X#, Hu J, Cui L, Zhao S, Jiao X*, Qin Y*. Dysregulated cytokine profile associated with biochemical premature ovarian insufficiency. Am J Reprod Immunol 2020; 84(4):e13292.
13. Jiao X#, Ke H, Qin Y, Chen ZJ. Molecular genetics of premature ovarian insufficiency. 2018, Trends Endocrinol Metab 29 (11), 795-807.
14. Gao J#, Jiao X#, Dang Y, Li J, Li G, Han T, Liu Y, Qin Y, Chen ZJ. Identification of patients with primary ovarian insufficiency caused by autoimmunity. 2017, Reprod Biomed Online 35 (4), 475-479.
15. Jiao X#, Zhang H#, Ke H, Zhang J, Cheng L, Liu Y, Qin Y, Chen ZJ. Premature Ovarian Insufficiency: Phenotypic Characterization Within Different Etiologies. 2017, J Clin Endocrinol Metab 102 (7), 2281-2290.
16. Qin Y#, Jiao X#, Dalgleish R, Vujovic S, Li J, Simpson JL, Al-Azzawi F, Chen ZJ. Novel variants in the SOHLH2 gene are implicated in human premature ovarian failure. 2014, Fertil Steril 101(4), 1104-1109.e6.
17. Jiao X#, Qin Y, Li G, Zhao S, You L, Ma J, Simpson JL, Chen ZJ. Novel NR5A1 missense mutation in premature ovarian failure: detection in Han Chinese indicates causation in different ethnic groups. 2013, PLoS One 8(9), e74759-e74759.
18. Jiao X#, Qin C, Li J, Qin Y, Gao X, Zhang B, Zhen X, Feng Y, Simpson JL, Chen ZJ. Cytogenetic analysis of 531 Chinese women with premature ovarian failure. 2012, Hum Reprod 27(7), 2201-2207.
